Anti-SOCS1: Mouse Suppressor of Cytokine Signaling 1 Antibody

BACKGROUND SOCS1 (Suppressor of cytokine signaling 1) is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. These family members are characterized by the presence of a src homology (SH2) domain and a carboxyl-terminal conserved domain called the SOCS box. So far, 8 members of the SOCS family have been identified, termed SOCS-1 to SOCS-7 and CIS (cytokine-inducible SH2-containing protein).¹ SOCS1 inhibits JAK-mediated cytokine signaling by binding to JAKs. It has been shown to be an important physiological negative regulator of various cytokines including IFNγ and IL-4. SOCS1 also modulates toll-like receptor (TLR) signaling in macrophages. SOCS1-deficient mice (SOCS1−/−) die neonatally because of multiorgan inflammation.² Recently, it was demonstrated that SOCS1 also participated in downstream signaling of receptor tyrosine kinase such as c-Kit and insulin receptor.³ In addition, SOCS1 has also been suggested to function as an antioncogene. Mutations and deletions of the SOCS1 gene have been found in several lymphomas.⁴

 

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4. Calabrese V et al.: Mol. Cell 36:754-767, 2009.