Renal Glomerular Epithelial Cells added to Human Kidney Cell Portfolio
SAN DIEGO, Nov 15, 2016 -- In order to provide investigators with more primary cell types for kidney disease research, Cell Applications, Inc. has launched Human Renal Glomerular Epithelial Cells (HRGEpC).  The glomerulus filters blood carried out by the nephron during urine formation, where blood plasma is sieved by passing through the glomerular membrane.  HRGEpC have received increasing attention lately as researchers work to understand renal pathophysiology, selective permeability, mechanosensing and contraction.  Problems with the glomerulus are a leading cause of kidney disease.  When activated, HRGEpC show elevated proliferation, migration and extracellular matrix production, activities possibly tied to glomerulonephritis, diabetic nephropathy and other pathologies.
As part of the Urogenital Cell group, CAI kidney cells also include Human Renal Proximal Tubular Epithelial Cells.  HRPTEpC play pivotal roles in kidney function, glucose & protein reabsorbtion, and diabetes-associated glucotoxicity.  HRPTEpC from Cell Applications, Inc. recently helped elucidate how metabolic enzymes respond to energy depletion.
Together, these two cell types offer a strong 1-2 punch in the research battle against serious, and potentially fatal loss of kidney function.  A number of conditions are related to dysfunction in this organ pair, including urinary tract infections, polycystic kidney disease, chronic kidney disease, diabetes and end-stage renal failure.  While the list of maladies is substantial, kidney disease can often be addressed by early detection, and hopes remain high to successfully treat more advances stages.
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