Product Sheet CB12146
Description
BACKGROUND Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B (AurkB) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AurkB functions in the attachment of the mitotic spindle to the centromere.1 In cancerous cells, over expression of these enzymes cause unequal distribution of genetic information creating aneuploidy cells, a hallmark of cancer. Thus, AurkB is emerging as a novel drug target for cancer treatment.2, 3
REFERENCES
1. Shannon, K. B. & Salmon, E.D.: Curr Biol. 12:R458, 2002.
2. Mahadevan, D. et al.: Curr Med Chem Anticancer Agents 3:25, 2003.
3. Vischioni, B. et al.: Mol. Cancer Ther. 5:2905, 2006.
2. Mahadevan, D. et al.: Curr Med Chem Anticancer Agents 3:25, 2003.
3. Vischioni, B. et al.: Mol. Cancer Ther. 5:2905, 2006.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
(Click to Enlarge) Specific detection of AurkB proteins from K562 cell lysate in Western blot analysis by AurkB Monoclonal Antibody (1F16).
Details
Cat.No.: | CB12146 |
Antigen: | Recombinant human Aurora Kinase B protein |
Applications & Suggested starting dilutions:* | WB 1:1000 IP n/d IHC n/d ICC n/d FACS n/d |
Molecular Weight of protein(KDa): | 41 kDa |
Species & predicted species cross-reactivity ( ): | Human, Mouse, Rat |
Specificity/Sensitivity: | Does not cross-react with other Aurora Kinase family proteins |
Storage: | Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.
Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Monoclonal Aurora Kinase B, AurkB, Antibody: Monoclonal Aurora Kinase B, AurkB, Antibody | Size: 100 ul | CAT.#: CB12146 | Price: $302.00 |