CAI Supports 2012 Nobel Research

CAI Cells and Products Support Nobel Prize-Winning Research, December 8, 2012
SAN DIEGO, Dec 8, 2012 -- Dr. Shinya Yamanaka of the Frontier Medical Sciences at Kyoto University and the J. David Gladstone Institutes at UCSF was awarded the 2012 Nobel Prize in Physiology or Medicine for the discovery that mature cells can be reprogrammed to become pluripotent.  His original paper was published in 2007 and was hailed as Time magazine's medical breakthrough of that year.  We are proud to be the primary cell provider for Dr. Yamanaka.
The following are selected publications that utilize Cell Applications, Inc. cells and cell culture products in Dr. Yamanaka’s work.  Representative items his lab used include Dermal Fibroblasts (HDF), Synoviocytes (HFLS) and Tissue RNA.
  • Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, Takahashi et al., Cell. 2007 Nov 30;131(5):861-72.
  • Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts, Nakagawa et al., Nat Biotechnol. 2008 Jan;26(1):101-6.
  • Human Induced Pluripotent Stem Cells on Autologous Feeders, Takahashi et al. PLoS One. 2009 Dec 2;4(12):e8067.
  • Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts, Tsubooka et al., Genes Cells. 2009 Jun;14(6):683-94.
  • Generation and characterization of human induced pluripotent stem cells Ohnuki et l., Curr Protoc Stem Cell Biol. 2009 Jun;Chapter 4:Unit 4A.2.
  • Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells, Takayama et al. J Exp Med. 2010 Dec 20;207(13):2817-30.
  • Generation of Human Melanocytes from Induced Pluripotent Stem Cells, Ohta et al., PLoS One. 2011 Jan 13;6(1):e16182.
  • ECAT11/L1td1 Is Enriched in ESCs and Rapidly Activated During iPSC Generation, but It Is Dispensable for the Maintenance and Induction of Pluripotency, Iwabuchi et l., PLoS One. 2011 6(5):e20461
  • An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells, Okita et al., Stem Cells. 2012 Nov 29.