Human subclavian artery smooth muscle cells (HScASMC ) are derived from the subclavian artery. They are cryopreserved at second passage. HScASMC can be cultured and propagated 12 population doublings. Morphology and growth characteristics of HScASMC from neonates were found to be different from those of adults1. A rabbit model using the subclavian artery was developed to study the temporal development and characteristics of an intimal cellular response and functional changes following balloon angioplasty injury2. Prolonged treatment with r-hirudin neither inhibits vascular smooth muscle cell proliferation in rabbits after angioplasty of the left subclavian artery nor reduces the size of neointimal lesion. This suggests r-hirudin treatment is not suitable as an antirestenotic intervention3. Subclavian-pulmonary artery anastomoses were created in Sprague-Dawley rats under different experimental conditions. It was found that the type of injury and the associated hemodynamic conditions could modify the elastic pulmonary response to injury4.
- Fujita H. et al, Exp Mol. Pathol. 1993 Feb; 58(1):25-39.
- Hadoke P, et al, Coron Artery Dis. 1995 May; 6(5):403-15.
- Hadoke PW, et al, Coron Artery Dis. 1996 Aug; 7(8):599-608.
- Tanaka Y, et al, J Clin Invest. 1996 Jul 15; 98(2):434-42.
Each lot tested negative for HIV, Hepatitis B and Hepatitis C and negative for mycoplasma, bacteria, yeast, fungi.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.