Human Brachiocephalic Artery Smooth Muscle Cells (HBcASMC) are primary smooth muscle cells isolated from normal brachiocephalic arteries and are cryopreserved at third passage. HBcASMC can be propagated at least 12 doublings. The brachiocephalic artery is the first branchfrom the aortic arch. HBcASMC provide an in vitro system to explore in vivo findings. Apolipoprotein E (apoE) knockout mice serve as a model for atherosclerotic lesion development, as fibrous plaques commonly form in the brachiocephalic artery after 6 months of a high-fat diet, thus providing a small well-defined area in which to study the progressive loss of plaque stability and eventual rupture1,2,3. p53 protects brachiocephalic and aortic smooth muscle cells against apoptosis while promoting apoptosis in macrophages, thus protecting against atherosclerosis development4. Reduced blood flow during pregnancy is associated with hypotrophy of the endothelial and smooth muscle cells of the carotid artery in the guinea pig5.
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Each lot tested negative for HIV, Hepatitis B and Hepatitis C and negative for mycoplasma, bacteria, yeast, fungi.
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