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Endothelial Cells

Endothelial cells (EC) line the blood vessels of the entire circulatory system, from aorta to capillaries, and act as a barrier between circulating blood and the rest of the vessel wall/surrounding tissues.  Endothelial cells are involved in the processes of angiogenesis, vasculogenesis, vasoregulation, coagulation, fibrinolysis and selective blood barrier.  They are also implicated in pathophysiological processes, including cardiovascular disease and cancer development.

All our endothelial cells are high purity, low passage, rigorously characterized, and performance tested. These endothelial cells demonstrate robust growth in Cell Applications, Inc.'s Growth Media: click on the video to the left to see these cells in culture. 

For your convenience, our endothelial cells are available as either cryovials, or as proliferating cells in flasks or multi-well plates. Cryopreserved endothelial cells are offered as part of user-friendly total kits that include optimized growth media and subculture reagent kits. The Total Kit includes all the supporting reagents you need to culture and passage the cells.

Matched smooth muscle cells obtained from the same arteries are available as well.  Co-culture of the endothelial cells with species- and vascular bed- matched smooth muscle cells provides an ideal model for studying the interaction between these two cell types.

Any of our endothelial cells can be additionally pre-screened (by customer request) to demonstrate stimulation-dependent angiogenesis and key endothelial cell signaling pathways (phosphorylation of VEGFR, Akt, MAPK, and expression of Tie2, eNOS, Axl and Etk/Bmx).  More information can be found on the Pre-Screened Endothelial Cell Product Page.

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