Bovine large artery smooth muscle cells are derived from tunica intima and tunica media of healthy, fibrous, plaque-free bovine pulmonary arteries. BPASMC are cryopreserved at second passage and can be cultured and propagated at least 16 population doublings. Smooth muscle cells have been found in fatty streaks of early arteriosclerosis. Proliferation of the smooth muscle cells is considered a key event in the development of advanced lesions1. They are an economical alternative suitable for investigations in cardiac disease and arteriosclerosis1-3, especially in co-culture with species-matched bovine arterial endothelial cells.
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McGill, H.C. Jr., Arteriosclerosis 4:443 (1984).
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