Human Mammary Epithelial Cells (HMEpC) are derived from normal adult mammary glands. They are cryopreserved at fifth passage. HMEpC can be cultured and propagated 16 population doublings. It was shown that normal HMEpC have a high amount of cyclin-dependent kinase 6 activity, which restrains HMEpC proliferation, and loss or down-regulation of cdk 6 may play a role in breast tumor development1. Transforming HMEpC to immortality and malignancy was a useful model for studying early breast carcinogenesis2. Autocrine colony-stimulating factor receptors may contribute to invasive progression in epithelial cancer was demonstrated in a 3-dimensional culture of HMEpC3.
Lucas, J.J. et al, Mol. Cancer Res. 2(2):105 (2004).
Stampfer, M.R. et al, J. Mammary Gland Biol. Neoplasia 5(4):365 (2000).
Wrobel, C.N. et al, J. Cell Bio.165(2):263 (2004).
Each lot tested negative for HIV, Hepatitis B and Hepatitis C and negative for mycoplasma, bacteria, yeast, fungi.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.