Endothelial cells are important parts of blood and lymph vessels. They play a pivotal role in a diverse range of physiological and pathophysiological processes from working as selective barrier between the blood and the surrounding bodily tissue to regulation of angiogenesis. They are closely involved in arterial disease and cancer development.
The most commonly used sources of human endothelial cells to study specific characteristics are Human Umbilical Vein Endothelial Cells, HUVEC, isolated from the vein of the umbilical cord, Human Microvascular Endothelial Cells, HMVEC, isolated from capillaries of the dermis and Human Aortic Endothelial Cells, HAOEC, isolated from capillaries of the aorta. At Cell Applications, primary cultures of HUVEC, HMVEC, and HAOEC were pre-screened for angiogenesis and other endothelial cell pathways by screening for phosphorylation events and protein levels of important signaling components including: VEGFR2 Akt MAPK, and others.