The pulmonary vasculature is of great physiological/pathological significance. It is now recognized to be a tissue composed of metabolically active, functionally responsive cells, that interact with circulating substrates and formed elements in ways that regulate the composition of systemic arterial blood, affect target organ functions, and contribute to thrombosis, hemostasis and immune reactions, as well as tumor metastasis1.
HLMVEC and elevated expression of chemoattractant cytokines are critical for directed migration of leucocytes into the lung during the induction and perpetuation of acute lung injury2. Human Lung Microvascular Endothelial Cells (HLMVEC) provide a useful tool for studying various aspects of pathology and biology of the pulmonary microvasculature in vitro.
1. Hewett, P.W.et al, Microvas. Res. 46:89 (1993)
2. McCuscey R, et al, Cardiovasc Res. 32:752 (1996)
Positive for factor VIII-related antigen expression.
Positive for CD31 expression.
Positive for metabolic activity by DiI-Ac-LDL uptake.
Each lot tested negative for HIV, Hepatitis B and Hepatitis C and negative for mycoplasma, bacteria, yeast, fungi.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.