Human Aortic Endothelial Cells (HAOEC) are primary endothelial cells isolated from normal human aorta. They are cryopreserved at second passage and can be cultured and propagated at least 16 population doublings. They respond to cytokine stimulation by expressing cell adhesion molecules. Aortic endothelial cells have been used as an in vitro model for the study of morphological and ultra-structural changes1 in the development of atherosclerosis. HAOEC system has also been used for the study of endothelial cell-dependent lymphocyte activation2 and chemoattractant activity for lymphocytes3 in relation to the degree of atherosclerosis.
Antonor, A.S. et al, Atherosclerosis 59:1 (1986).
Ashida, E.R. et al, J. Clin. Invest. 67:1490 (1981).
Farber, H.W. et al, Amer. J. Physiol. 262 (4 parts): H1088 (1992)
Characterization: Positive for Factor VIII-related antigen expression. Positive for Dil-Ac-LDL uptake.
Endothelial Cells play a pivotal role in a diverse range of physiological processes, such as angiogenesis and as the selective blood barrier; and pathophysiological processes, including arterial disease and cancer development. At Cell Applications, select lots of HAOEC, HUVEC, and HMVEC undergo an additional set of characterization to demonstrate stimulation-dependent angiogenesis and other endothelial cell signaling pathways.
Each lot tested negative for HIV, Hepatitis B and Hepatitis C and negative for mycoplasma, bacteria, yeast, fungi.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.