Human Skeletal Muscle Cells (HSkMC) are isolated from the skeletal muscle of limbs. They are cryopreserved at second passage and can be cultured and propagated for at least 15 population doublings. Human Skeletal Muscle Cells can undergo differentiation to exhibit actin and myosin myofilaments. HSkMC have been used in the study of genetic muscular diseases such as Malignant Hyperthermia1. HSkMC also have the potential to act as a cardiac graft, mending damage to the heart2. Recently, cultured Human Skeletal Muscle cells have been used in micro gravity experiments to study the effects of low gravity environments on Human Skeletal Muscle3.
O’Sullivan, G.H. et al, Biochem Pharmacol 61(12):1479-1485 (2001)
El Oakley, R.M. et al, Ann. Thorac. Surg. 71(5):1724-1733 (2001)
Slentz, D.H. et al, In Vitro Cell. Dev. Biol. Anim. 37(3):148-156 (2001)
Characterization: Positive for sarcomere myosin.
Skeletal Muscle Cells play an instrumental role in the glucose metabolism and diabetes, thus select HSkMC lots undergo an additional set of characterization at Cell Applications, to demonstrate that Insulin & AMPK signaling is sensitive to insulin stimulation. Click on the link below to learn more.
Each lot tested negative for HIV, Hepatitis B and Hepatitis C and negative for mycoplasma, bacteria, yeast, fungi.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.