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CnC: Canine Chondrocytes



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Canine Chondrocytes, CnC

Canine Chondrocytes (CnC) are isolated from normal canine articular cartilage. They are cryopreserved at first passage and can be cultured and propagated at least 10 population doublings. CnC cultured in agarose 3-D constructs of osteoarthritis (OA) model were used to test the effect of carpofen and dexamethasone1. Porous gene-supplemented collagen-glycosaminoglycan (GSCG) matrices were fabricated to provide sustained release of plasmid DNA carrying therapeutic gene to articular chondrocytes2. Autologous chondrocyte implantation (ACI) in a canine model was evaluated in terms of change in composition of reparative tissue with time3. Cultured autologous chondrocytes were used in treating articular cartilage defects as compared with microfracture, a type-II collagen matrix4.
  1. Dvorak, L.D. et al, Am. J. Vet. Res. 63(10):1363-9 (2002).
  2. Samuel, R.E. et al, Hum. Gene Ther. 13(7):791-802 (2002).
  3. Breinan, H.A. et al, J. Orthop. Res. 19(3):482-92 (2001).
  4. Breinan, H.A. et al, J. Ortho. Res. 18(5):781-9 (2000).
Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Tissue:
Normal canine articular cartilage
Cryopreserved ampoule:
1st passage, >500,000 cells in Canine Chondryocyte Basal Medium containing 10% FBS & 10% DMSO.
Kit contains:
Ampoule of cryopreserved CnC (Cn402-05), 500 ml Canine Chondrocyte Growth Medium (Cn411-500), and a Subculture Reagent Kit (090K).
Proliferating Cells:
 
Shipped in Canine Chondrocyte Growth Medium at 2nd passage in either flasks or multiwell dishes.
Population doublings:
Can be cultured at least 10 doublings

Call 800-645-0848 or 858-453-0848 to place an order.
Cell Products
Product Name Product Description Size Cat. No. Price
Cryopreserved CnC Each kit contains an ampoule of >500,000 cryopreserved cells, 500 ml of Canine Chondrocyte Growth Medium (Cn411-500), and a Subculture Reagent Kit. 1 Kit
1 Ampoule 		Cn402K-05
Cn402-05 		$728
$595
Proliferating CnC Cultured and shipped at second passage in Canine Chondrocyte Growth Medium. T-25 Flask
T-75 Flask
6 well
96 well 		Cn403-25
Cn403-75
Cn403-6W
Cn403-96W 		$595
$785
$785
$905
 
Media and Reagents
Product Name Product Description Size Cat. No. Price
Canine Chondrocyte Growth Medium Optimized and ready for use. 500 ml Cn411-500 $92
Canine Chondrocyte Growth Medium Kit Basal Medium & Growth Supplement packaged separately. Yields 500 ml Cn411K-500 $105
Canine Chondrocyte Basal Medium Add Growth Supplement before use. 500 ml Cn410-500 $53
Canine Chondrocyte Growth Supplement Added to Basal Medium to create Growth Medium 50 ml Cn411-GS $47
Canine Chondrocyte Differentiation Medium Canine Chondrocyte Differentiation Medium 250 ml Cn411D-250 $66
Subculture Reagent Kit 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution 100 ml 090K $51