Human Bronchial/Tracheal Epithelial Cells (HBEpC/HTEpC)

Chemical target and pathway toxicity mechanisms defined in primary human cell systems.
Berg, E, Yang, J, Melrose, J, Nguyen, D, Privat, S, Rosler, E, Kunkel, EJ and Ekins, S.
J. Pharmacol. Toxicol. Methods January-February 2010, 61 (1) 3-15.

MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium.
Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A.
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2319-24. Epub 2009 Jan 23.

Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells.
Tanaka H, Fukushima T, Yorita K, Kawaguchi M, Kataoka H.
Hum Cell. 2009 Feb;22(1):11-7.

Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, Yagihashi S, Shinkawa H.
BMC Cancer. 2008 Nov 26;8:348.

Hepatocyte growth factor regulates cyclooxygenase-2 expression via beta-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells.
Lee YH, Suzuki YJ, Griffin AJ, Day RM.
Am J Physiol Lung Cell Mol Physiol. 2008 Apr;294(4):L778-86. Epub 2008 Feb 1

Amino acid 226 in Hemagglutinin of H9N2 influenza viruses determines cell tropism and replication in human airway epithelial cells.
HQ Wan, D Perez.
J Virol. 2007 May;81:5181-91.

SPDEF regulates goblet cell hyperplasia in the airway epithelium.
KS Park, TR Korfhagen, MD Bruno, JA Kitzmiller, H Wan H, Wert SE, Khurana Hershey GK, Chen G, Whitsett JA.
J Clin Invest. 2007 Apr;117(4):978-88.

E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein.
K Handa, T Yugawa, M Narisawa-Saito, S Ohno, M Fujita, T Kiyono.
J Virol. 2007 Feb;81(3):1379-89.

Efficient immortalization of primary human cells by p16[INK4a]-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.
K Haga, S Ohno, T Yugawa, M Narisawa-Saito, M Fujita, M Sakamoto, DA Galloway, T Kiyono.
Cancer Sci. 2007 Feb;98(2):147-54.

Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells.
HY Tai, MF Tam, H Chou, HJ Peng, SN Su, DW Perng.
Allergy. 2006 Mar;61(3):382-8.

Comparison of the activities of granulocyte-macrophage colony-stimulating factor and interleukin-8 secretion between two lung epithelial cell lines.
SC Lee, JY Hsu, LS Fu, JJ Chu, SJ Fan, CS Chi.
J Microbiol Immunol Infect. 2005 Oct;38(5):327-31.

Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins.
E Leikina, H Delanoe-Ayari, K Melikov, MS Cho, A Chen, AJ Waring, W Wang, Y Xie, JA Loo, RI Lehrer, LV Chernomordik.
Nat Immunol. 2005 Oct;6(10):995-1001.

Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-dependent mechanisms.
DC Look, LL Stoll, SA Romig, A Humlicek, BE. Britigan, GM Denning.
J Immunol. 2005 Sep 15;175(6):4017-23.

RSV causes HIF-1alpha stabilization via NO release in primary bronchial epithelial cells.
MM Kilani, KA Mohammed, N Nasreen, RS Tepper, VB Antony.
Inflammation. 2004 Oct;28(5):245-51.

Respiratory syncytial virus causes increased bronchial epithelial permeability.
MM Kilani, KA Mohammed, N Nasreen, JA Hardwick, MH Kaplan, RS Tepper, VB Antony.
Chest. 2004 Jul;126(1):186-91.

The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells
YQ O'Malley, KJ Reszka, GT Rasmussen, MY Abdalla, GM Denning, BE Britigan.
Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1077-86.

Human Chondrocytes (HC)

Desirable effect of combination therapy with high molecular weight hyaluronate and NSAIDs on MMP production.
Hashizume M, Mihara M.
Osteoarthritis Cartilage. 2009 May 5.

Increased chondrocyte adhesion on nanotubular anodized titanium.
Burns K, Yao C, Webster TJ.
J Biomed Mater Res A. 2009 Mar 1;88(3):561-8.

IL-1beta stimulates the expression of prostaglandin receptor EP4 in human chondrocytes by increasing production of prostaglandin E2
Watanabe Y, Namba A, Honda K, Aida Y, Matsumura H, Shimizu O, Suzuki N, Tanabe N, Maeno M.
Connect Tissue Res. 2009;50(3):186-93

Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-Jun N-terminal kinase, and Bax-mitochondria-mediated caspase activation.
Cherng YG, Chang HC, Lin YL, Kuo ML, Chiu WT, Chen RM.
J Orthop Res. 2008 Jul;26(7):1018-26

Enhanced chondrocyte densities on carbon nanotube composites: the combined role of nanosurface roughness and electrical stimulation.
Khang D, Park GE, Webster TJ.
J Biomed Mater Res A. 2008 Jul;86(1):253-60.

Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis.
CPD Le Visage, SW Kim, K Tateno, AN Sieber, JP Kostuik, KW Leong
Spine. 2006 Aug 15;31(18):2036-42.

Novel p38 mitogen-activated protein kinase inhibitor R-130823 protects cartilage by down-regulating matrix metalloproteinase-1,-13 and prostaglandin E2 production in human chondrocytes.
Y Wada, K Shimada, K Sugimoto, T Kimura, S Ushiyama
Int Immunopharmacol. 2006 Feb;6(2):144-55.

Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis.
J Quintavalla, C Kumar, S Daouti, E Slosberg, S Uziel-Fusi
J Cell Physiol. 2005 Aug;204(2):560-6.

Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds.
GE Park, MA Pattison, K Park, TJ Webster
Biomaterials. 2005 Jun;26(16):3075-82.

Induction of Host Matrix Metalloproteinases by Borrelia burgdorferi Differs in Human and Murine Lyme Arthritis.
AK Behera, E Hildebrand, J Scagliotti, AC Steere, LT Hu
Infect Immun. 2005 Jan;73(1):126-34.

Nanometer surface roughness increases select osteoblast adhesion on carbon nanofiber compacts.
RL Price, K Ellison, KM Haberstroh, TJ Webster
J Biomed Mater Res A. 2004 Jul 1;70(1):129-38.

Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases from Human Chondrocytes Requires Mitogen-Activated Protein Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathways.
AK Behera, CM Thorpe, JM Kidder, W Smith, E Hildebrand, LT Hu
Infect Immun. 2004 May;72(5):2864-71.

Altered responses of chondrocytes to nanophase PLGA/nanophase titania composites.
JK Savaiano, TJ Webster
Biomaterials. 2004 Mar-Apr;25(7-8):1205-13.

Nanostructured polymer/nanophase ceramic composites enhance osteoblast and chondrocyte adhesion.
S Kay, A Thapa, KM Haberstroh, TJ Webster
Tissue Eng. 2002 Oct;8(5):753-61.

Identification and characterization of the human long form of Sox5 (L-SOX5) gene.
T Ikeda, J Zhang, T Chano, A Mabuchi, A Fukuda, H Kawaguchi, K Nakamura, S Ikegawa
Gene. 2002 Sep 18;298(1):59-68.

Osteoblast and Chrondrocyte Proliferation in the Presence of Alumina And Titania Nanoparticles.
LG Gutwein, TJ Webster
Journal of Nanoparticle Research. 2002 June 4(3):231-238(8)

Differences in Synovial Fluid Levels of Matrix Metalloproteinases Suggest Separate Mechanisms of Pathogenesis in Lyme Arthritis before and after Antibiotic Treatment.
B Lin, JM Kidder, R Noring, AC Steere, MS Klempner, LT Hu
The Journal of Infectious Diseases. 2001;184:174–80

Human Fibroblast-Like Synoviocytes (HFLS)

CCAAT/enhancer binding protein β regulates expression of matrix metalloproteinase-3 in arthritis.
Tsushima, H., Okazaki, K., Hayashida, M., Ushijima, T., Iwamoto, Y.
Ann. Rheum. Dis. 2012; 71:99–107.

Novel hyaluronic acid-methotrexate conjugates for osteoarthritis treatment.
Homma A, Sato H, Okamachi A, Emura T, Ishizawa T, Kato T, Matsuura T, Sato S, Tamura T, Higuchi Y, Watanabe T, Kitamura H, Asanuma K, Yamazaki T, Ikemi M, Kitagawa H, Morikawa T, Ikeya H, Maeda K, Takahashi K, Nohmi K, Izutani N, Kanda M, Suzuki R.
Bioorg Med Chem. 2009 Jul 1;17(13):4647-56. Epub 2009 May 3.

MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Nakamachi Y, Kawano S, Takenokuchi M, Nishimura K, Sakai Y, Chin T, Saura R, Kurosaka M, Kumagai S.
Arthritis Rheum. 2009 May;60(5):1294-304.

**Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.
Mathieu MC, Lord-Dufour S, Bernier V, Boie Y, Burch JD, Clark P, Denis D, Han Y, Mortimer JR, Therien AG.
Eur J Immunol. 2008 Jul;38(7):1900-12.

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors.
K Takahashi, K Tanabe, M Ohnuki, M Narita, T Ichisaka, K Tomoda, S Yamanaka
Cell. 2007 Nov 30; 131(5): 861-872.

Effects of Levofloxacin and Doxycycline on Interleukin-6 Production of Chlamydia trachomatis-Infected Human Synovial Fibroblasts.
Y Ikeda-Dantsuji, I Konomi, A Nagayama
Chemotherapy. 2007;53:332-337.

TWEAK Is a Novel Arthritogenic Mediator.
SJ Perper, B Browning, LC Burkly, S Weng, C Gao, K Giza, L Su, L Tarilonte, T Crowell, L Rajman, L Runkel, M Scott, GJ Atkins, DM Findlay,  TS Zheng, H Hess
J Immunol. 2006 Aug 15;177(4):2610-20.

A Selective Small Molecule IKK-beta Inhibitor Blocks NF-kappa-B Mediated Inflammatory Responses in Human Fibroblast Like Synoviocytes, Chondrocytes and Mast Cells.
D Wen, Y Nong, JG Morgan, P Gangurde, A Bielecki, J DaSilva, M Keaveney, H Cheng, C Fraser, L Schopf, M
Hepperle, G Harriman, BD Jaffee, TD Ocain, Y Xu
J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001.

PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes.
HS Cha, S Rosengren, DL Boyle, GS Firestein
Arthritis Rheum. 2006 Feb;54(2):587-92.

Activation of synoviocytes by the secreted phospholipase A2 motif in the VP1-unique region of parvovirus B19 minor capsid protein.
J Lu, N Zhi, S Wong, KE Brown
J Infect Dis. 2006 Feb 15;193(4):582-90.

Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982.
Y Wada, K Shimada, T Kimura, S Ushiyama
Immunology Letters. 2005 October 101(1):50-59.

AGIX-4207, a novel antioxidant and anti-inflammatory compound: I. Cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.
C Kunsch, J Luchoomun, X Chen, G Dodd, K Karu, CQ Meng, EM Marino, LK Olliff, JD Piper, FH Qiu, JA Sikorski, PK Somers, KL Suen, S Thomas, AM Whalen, MA Wasserman, CL Sundell
J Pharmacol Exp Ther. 2005 May;313(2):492-501.

Human Fibroblast-Like Synoviocytes, Rheumatoid Arthritis (HFLS-RA)

Celastrus-derived Celastrol Suppresses Autoimmune Arthritis by Modulating Antigen-induced Cellular and Humoral Effector Responses.
Venkatesha, S.H., Yu, H., Rajaiah, R., Tong, L. and Moudgil, K.D.
JBC Papers in Press, March 14, 2011, DOI 10.1074/jbc.M111.226365.

Increased Levels of Interleukin 33 in Sera and Synovial Fluid from Patients with Active Rheumatoid Arthritis.
Matsuyama, Y., Okazaki, H., Tamemoto, H., Kimura, H., Kamata, Y., Nagatani, K., Nagashima, T., Hayakawa, M., Iwamoto, M., Yoshio, T., Tominaga, S. and Minota, S.
J. Rheumatol, Jan 2010; 37: 18 - 25.

Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes.
Yamaura M, Yao M, Yaroslavsky I, Cohen R, Smotrich M, Kochevar IE.
Lasers Surg Med. 2009 Apr;41(4):282-90.

Thrombin-stimulated proliferation of cultured human synovial fibroblasts through proteolytic activation of proteinase-activated receptor-1.
Furuhashi I, Abe K, Sato T, Inoue H.
 J Pharmacol Sci. 2008 Sep;108(1):104-11. Epub 2008 Sep 11

**Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.
Mathieu MC, Lord-Dufour S, Bernier V, Boie Y, Burch JD, Clark P, Denis D, Han Y, Mortimer JR, Therien AG.
Eur J Immunol. 2008 Jul;38(7):1900-12.

PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes.
HS Cha, S Rosengren, DL Boyle, GS Firestein
Arthritis Rheum. 2006 Feb;54(2):587-92.

Activation of synoviocytes by the secreted phospholipase A2 motif in the VP1-unique region of parvovirus B19 minor capsid protein.
J Lu, N Zhi, S Wong, KE Brown
J Infect Dis. 2006 Feb 15;193(4):582-90.

Regulation of neurokinin-1 receptor messenger RNA expression in synovial fibroblasts of patients with rheumatoid arthritis.
Y Akasaka, K Abe, T Sato, H Inoue
Neuropeptides. 2005 Oct;39(5):467-74.

The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis.
JC Keith Jr, LM Albert, Y Leathurby, M Follettie, L Wang, L Borges-Marcucci, CC Chadwick, RJ Steffan, and DC Harnish
Arthritis Res Ther. 2005;7(3):R427-38.

A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
SG Bernier, DD Lazarus, E Clark, B Doyle, MT Labenski, CD Thompson, WF Westlin, G Hannig
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10768-73.

Differences in Synovial Fluid Levels of Matrix Metalloproteinases Suggest Separate Mechanisms of Pathogenesis in Lyme Arthritis before and after Antibiotic Treatment.
Bo Lin, JM Kidder, R Noring, AC Steere, MS Klempner, LT Hu
The Journal of Infectious Diseases. 2001;184:174–80.

Adenoviral vectors expressing siRNAs for discovery and validation of gene function.
GJ Arts, E Langemeijer, R Tissingh, L Ma, H Pavliska, K Dokic, R Dooije, E Mesic, R Clasen, F Michiels, J Schueren, M Lambrecht, S Herman, R Brys, K Thys, M Hoffmann, P Tomme, H van Es
Genome Res. 2003 Oct;13(10):2325-32.

Production of interleukin-6, but not interleukin-8, induced by TNF-alpha or IL-1 beta in human fibroblast-like synoviocyte increases over cell passage.
SJ Privat, A Oo, LD Waterbury
Proc West Pharmacol Soc. 2001;44:9-13.

Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor.
K Yano, N Nakagawa, H Yasuda, E Tsuda, K Higashio
J Bone Miner Metab. 2001;19(6):365-72.

Human Fibroblast-Like Synoviocytes, Osteo Arthritis (HFLS-OA)

A functional SNP in EDG2 increases susceptibility to knee osteoarthritis.
Mototani H, Iida A, Nakajima M, Furuichi T, Miyamoto Y, Tsunoda T, Sudo A, Kotani A, Uchida A, Ozaki K, Tanaka Y, Nakamura Y, Tanaka T, Notoya K, Ikegawa S.
Hum Mol Genet. 2008 Jun 15;17(12):1790-7. Epub 2008 Mar 6.

Activation of synoviocytes by the secreted phospholipase A2 motif in the VP1-unique region of parvovirus B19 minor capsid protein.
J Lu, N Zhi, S Wong, KE Brown
J Infect Dis. 2006 Feb 15;193(4):582-90.

PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes.
HS Cha, S Rosengren, DL Boyle, GS Firestein
Arthritis Rheum. 2006 Feb;54(2):587-92.

**Actions and comparative efficacy of phosphatidylcholine formulation and isolated sodium deoxycholate for different cell types.
Gupta A, Lobocki C, Singh S, Robertson M, Akadiri OA, Malhotra G, Jackson IT.
Aesthetic Plast Surg. 2009 May;33(3):346-52. Epub 2009 Feb 7.

Chemokine-like factor expression in the idiopathic inflammatory myopathies.
Chowdhury MH, Nagai A, Terashima M, Sheikh A, Murakawa Y, Kobayashi S, Yamaguchi S.
Acta Neurol Scand. 2008 Aug;118(2):106-14. Epub 2008 Feb 19.

Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells.
H Yamazaki, M Suzuki, T Aoki, S Morikawa, T Maejima, F Sato, K Sawanobori, M Kitahara, T Kodama, Y Saito.
J Atheroscler Thromb. 2006 Dec;13(6):295-307.

Control of developmental regulators by Polycomb in human embryonic stem cells.
TI Lee, RG Jenner, LA Boyer, MG Guenther, SS Levine, RM Kumar, B Chevalier, SE Johnstone, MF Cole, K Isono, H Koseki, T Fuchikami, K Abe, HL Murray, JP Zucker, B Yuan, GW Bell, E Herbolsheimer, NM Hannett, K Sun, DT Odom, AP Otte, TL Volkert, DP Bartel, DA Melton, DK Gifford, R Jaenisch, RA Young.
Cell. 2006 Apr 21;125(2):301-13.

Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation.
JR Patton, Y Bykhovskaya, E Mengesha, C Bertolotto, N Fischel-Ghodsian
J Biol Chem. 2005 May 20;280(20):19823-8.

PKC/MAPK signaling suppression by retinal pericyte conditioned medium prevents retinal endothelial cell proliferation.
T Kondo, K Hosoya, S Hori, M Tomi, S Ohtsuki, T Terasaki
 J Cell Physiol. 2005 May;203(2):378-86.

Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins.
S Morikawa, T Murakami, H Yamazaki, A Izumi, Y Saito, T Hamakubo, T Kodama
J Atheroscler Thromb. 2005;12(3):121-31.

Expression and stability of two isoforms of ABCG1 in human vascular cells.
Gelissen IC, Cartland S, Brown AJ, Sandoval C, Kim M, Dinnes DL, Lee Y, Hsieh V, Gaus K, Kritharides L, Jessup W.
Atherosclerosis. 2009 Jul 8. [Epub ahead of print]

Paclitaxel induces up-regulation of tissue factor in human aortic endothelial cells.
Wang HJ, Huang H, Chuang YC, Huang HC.
 Int Immunopharmacol. 2009 Jan;9(1):144-7. Epub 2008 Nov 6.

**p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.
Kim CS, Jung SB, Naqvi A, Hoffman TA, DeRicco J, Yamamori T, Cole MP, Jeon BH, Irani K.
Circ Res. 2008 Dec 5;103(12):1441-50. Epub 2008 Nov 6.

**A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
Yamanaka M, Anada Y, Igarashi Y, Kihara A.
Biochem Biophys Res Commun. 2008 Oct 31;375(4):675-9. Epub 2008 Aug 26.

Protective effects of a compound herbal extract (Tong Xin Luo) on free fatty acid induced endothelial injury: implications of antioxidant system.
Zhang L, Wu Y, Jia Z, Zhang Y, Shen HY, Wang XL.
 BMC Complement Altern Med. 2008 Jul 14;8:39.

Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells.
Maghzal GJ, Thomas SR, Hunt NH, Stocker R.
J Biol Chem. 2008 May 2;283(18):12014-25. Epub 2008 Feb 25.

Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells.
Li X, Rong Y, Zhang M, Wang XL, LeMaire SA, Coselli JS, Zhang Y, Shen YH.
Biochem Biophys Res Commun. 2009 Apr 17;381(4):660-5. Epub 2009 Feb 28.

Thrombin Induces the Expression of Tissue Factor in Human Aortic Endothelial Cells
HJ Wang, HC Huang, YC Chuang, H Huang.
Acta Cardiol Sin 2008;24:151-6.

Covalent binding of rofecoxib, but not other cyclooxygenase-2 inhibitors, to allysine aldehyde in elastin of human aorta.
M Oitate, T Hirota, T Murai, S Miura, T Ikeda
Drug Metab Dispos. 2007 Oct;35(10):1846-52.

Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis.
SC Hung, RR Pochampally, SC Chen, SC Hsu, DJ Prockop
Stem Cells. 2007 Sep;25(9):2363-70.

Role for Gingipains in Porphyromonas gingivalis Traffic to Phagolysosomes and Survival in Human Aortic Endothelial Cells.
K Yamatake, M Maeda, T Kadowaki, R Takii, T Tsukuba, T Ueno, E Kominami, S Yokota, K Yamamoto
Infect Immun. 2007 May;75(5):2090-100.

Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38.
P Qin, X Tang, MM Elloso, DC Harnish
Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H741-7.

Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells.
YH Shen, L Zhang, Y Gan, X Wang, J Wang, SA LeMaire, JS Coselli, XL Wang
J Biol Chem. 2006 Mar 24;281(12):7727-36.

Elevated Concentrations of Nonesterified Fatty Acids Increase Monocyte Expression of CD11b and Adhesion to Endothelial Cells.
WY Zhang, E Schwartz, Y Wang, J Attrep, Z Li, P Reaven
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):514-9.

Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta.
X Tang, BB Holmes, K Nithipatikom, CJ Hillard, H Kuhn, WB Campbell.
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):78-84.

Kinetic analysis of cytokine response to cigarette smoke condensate by human endothelial and monocytic cells.
BK Nordskog, WR Fields, GM Hellmann
Toxicology. 2005 Sep 1;212(2-3):87-97.

Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase.
Y Gan, YH Shen, J Wang, X Wang, B Utama, XL Wang
J Biol Chem. 2005 Apr 22;280(16):16467-75.

Endogenous nitric oxide activation protects against cigarette smoking induced apoptosis in endothelial cells.
M Raveendran, J Wang, D Senthil, J Wang, B Utama, Y Shen, D Dudley, Y Zhang, XL Wang
FEBS Lett. 2005 Jan 31;579(3):733-40.

Effects of 4-hydroxy-2-nonenal on cultured human aortic endothelial cells and myocardial cell.
J Xu, JL Zhou, NF Wang, HY Xu
Conf Proc IEEE Eng Med Biol Soc. 2005;6(1):5598-5602.

Cigarette suppresses the expression of P4Halpha and vascular collagen production.
M Raveendran, D Senthil, B Utama, Y Shen, D Dudley, J Wang, Y Zhang, XL Wang
Biochem Biophys Res Commun. 2004 Oct 15;323(2):592-8.

Overexpression of uncoupling protein 2 in THP1 monocytes inhibits beta2 integrin-mediated firm adhesion and transendothelial migration.
JW Ryu, KH Hong, JH Maeng, JB Kim, J Ko, JY Park, KU Lee, MK Hong, SW Park, YH Kim, KH Han
Arterioscler Thromb Vasc Biol. 2004 May;24(5):864-70.

MMP-1 polymorphic expression in aortic endothelial cells: Possible role in lesion development in smokers and nonsmokers.
BK Nordskog, AD Blixt, AW Zieske, GM Hellmann
Cardiovascular Toxicology. 2004 March 4(1):75-83.

Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR.
R Pullmann Jr, M Juhaszova, IL de Silanes, T Kawai,  K Mazan-Mamczarz K, MK Halushka, M Gorospe
J Biol Chem. 2005 Jun 17;280(24):22819-26.

Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration.
SA DeLong, JJ Moon, JL West
Biomaterials. 2005 Jun;26(16):3227-34.

Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions.
SP Gravel, MJ Servant
J Biol Chem. 2005 Mar 4;280(9):7477-86.

GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats.
CJ Meininger, S Cai, JL Parker, KM Channon, KA Kelly, EJ Becker, MK Wood, LA Wade, G Wu
FASEB J. 2004 Dec;18(15):1900-2.

Fibronectin Polymerization Regulates the Composition and Stability of Extracellular Matrix Fibrils and Cell-Matrix Adhesions.
J Sottile and DC Hocking
Mol Biol Cell. 2002 October; 13(10): 3546–3559.

Disruption of Nrf2 Signaling Impairs Angiogenic Capacity of Endothelial Cells: Implications for Microvascular Aging.
Valcarcel-Ares, M.N., Gautam, T., Warrington, J.P., Bailey-Downs, L., Sosnowska, D., de Cabo, R., Losonczy, G., Sonntag, W.E., Ungvari, Z. and Csiszar, A.
J. Gerontol. A. Biol. Sci. Med. Sci. 2012. doi:10.1093/gerona/glr229.

Niacin Inhibits Vascular Inflammation via the Induction of Heme Oxygenase-1.
Wu, B.J., Chen, K., Barter, P.J. and Rye, K.
Circulation 2012, 125:150-158.

Comparative gene expression analysis between coronary arteries and internal mammary arteries identifies a role for the TES gene in endothelial cell functions relevant to coronary artery disease.
Archacki, S.R., Angheloiu, G., Moravec, C.S., Liu, H., Topo, E.J. and Wang, Q.K.
Human Molecular Genetics, 2011; 1–10 doi:10.1093/hmg/ddr574.

Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning.
Vladic, N., Ge, Z., Leucker, T., Brzezinska, A.K., Du, J., Shi, Y., Warltier, D.C., Pratt Jr., P.F. and Kersten, J.R.
Am. J. Physiol. Heart Circ. Physiol. 301:H2130-H2139, 2011.

Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging.
Bailey-Downs, L.C., Mitschelen, M., Sosnowska, D., Toth, P., Pinto, J.T., Ballabh, P., Valcarcel-Ares, M.N., Farley, J., Koller, A., Henthorn, J.C., Bass, C., Sonntag, W.E., Ungvari, Z. and Csiszar, A. J Gerontol A Biol Sci Med Sci, Oct 2011; 10.1093/gerona/glr164.

Elevated soluble fms-like tyrosine kinase-1 levels in acute coronary occlusion.
Kapur, NK, Heffernan, KS, Yunis, AA, Nguyen, TA, Aronovitz, MJ, Parpos, P, Wilson, S, Baker, CK, Esposito, ML, Shah, A, Kimmelstiel, CD, Weintraub, A, Karas, RH, Mendelsohn, ME.
Arterioscler. Thromb. Vasc. Biol. 2010 31: 443-450.

(-)-Epicatechin Activation of Endothelial Cell Endothelial Nitric Oxide Synthase, Nitric Oxide, and Related Signaling Pathways.
Ramirez-Sanchez, I., Maya, L., Ceballos, G. and Villarreal, F.
Hypertension, Jun 2010; 55: 1398 - 1405.

Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells
Rajesh, M , Mukhopadhyay, P., Haskó, G.
British J. Pharm. (2010), 160, 688 -700.

Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering.
Singelyn JM, DeQuach JA, Seif-Naraghi SB, Littlefield RB, Schup-Magoffin PJ, Christman KL.
Biomaterials. 2009 Oct;30(29):5409-16. Epub 2009 Jul 15.

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.
Csiszar A, Labinskyy N, Jimenez R, Pinto JT, Ballabh P, Losonczy G, Pearson KJ, de Cabo R,
Ungvari Z.
Mech Ageing Dev. 2009 Aug;130(8):518-27. Epub 2009 Jun 21

Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering.
Singelyn JM, Dequach JA, Seif-Naraghi SB, Littlefield RB, Schup-Magoffin PJ, Christman KL.
Biomaterials. 2009 Jul 14. [Epub ahead of print]

*Synergistic drug combinations tend to improve therapeutically relevant selectivity.
Lehár J, Krueger AS, Avery W, Heilbut AM, Johansen LM, Price ER, Rickles RJ, Short GF 3rd, Staunton JE, Jin X, Lee MS, Zimmermann GR, Borisy AA.
Nat Biotechnol. 2009 Jul;27(7):659-66. Epub 2009 Jul 5.

Role of 3beta-hydroxysteroid-delta 24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells.
McGrath KC, Li XH, Puranik R, Liong EC, Tan JT, Dy VM, DiBartolo BA, Barter PJ, Rye KA, Heather AK.
Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):877-82. Epub 2009 Mar 26.

Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft microdomains.
Ji SR, Ma L, Bai CJ, Shi JM, Li HY, Potempa LA, Filep JG, Zhao J, Wu Y.
FASEB J. 2009 Jun;23(6):1806-16. Epub 2009 Jan 9.

Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.
Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF Jr, Kersten JR.
Anesthesiology. 2009 Feb;110(2):317-25.

Characterization of an NbTaWZr alloy designed for magnetic resonance angiography compatible stents.
O'Brien BJ, Stinson JS, Boismier DA, Carroll WM.
Biomaterials. 2008 Dec;29(34):4540-5. Epub 2008 Sep 14.

High-density lipoprotein reduces the human monocyte inflammatory response.
Murphy AJ, Woollard KJ, Hoang A, Mukhamedova N, Stirzaker RA, McCormick SP, Remaley AT, Sviridov D, Chin-Dusting J.
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2071-7. Epub 2008 Jul 10.

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.
Csiszar A, Labinskyy N, Perez V, Recchia FA, Podlutsky A, Mukhopadhyay P, Losonczy G, Pacher P, Austad SN, Bartke A, Ungvari Z.
Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1882-94. Epub 2008 Aug 29.

**Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells.
Csiszar A, Labinskyy N, Jo H, Ballabh P, Ungvari Z.
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H569-77. Epub 2008 Jun 6.

2-Chlorohexadecanal and 2-chlorohexadecanoic acid induce COX-2 expression in human coronary artery endothelial cells.
Messner MC, Albert CJ, Ford DA.
Lipids. 2008 Jul;43(7):581-8. Epub 2008 May 21.

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.
Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R, Ballabh P, Ungvari Z.
Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35. Epub 2008 Apr 18.

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats.
Ungvari Z, Labinskyy N, Gupte S, Chander PN, Edwards JG, Csiszar A.
J Clin Invest. 2008 Feb;118(2):505-14Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2121-8. Epub 2008 Mar 7.

Identification of Lysophosphatidylcholine–Chlorohydrin in Human Atherosclerotic Lesions
Messner MC, Albert CJ, McHowat J, Ford DA.
Lipids. 2008 Mar;43(3):243-9. Epub 2008 Feb 7.

Strikingly Different Angiogenic Properties of Endothelial Progenitor Cell Subpopulations
J Am Coll Cardiol. 2008 Feb 12;51(6):660-8.
Sieveking DP, Buckle A, Celermajer DS, Ng MK.

CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
M Rajesh, P Mukhopadhyay, S Batkai, G Hasko, L Liaudet, JW Huffman, A Csiszar, Z Ungvari, K Mackie, S Chatterjee, P Pacher
Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2210-8.

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption.
M Rajesh, P Mukhopadhyay, S Batkai, G Hasko, L Liaudet, VR Drel, IG Obrosova, P Pacher
Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H610-9.

Simple quantitative detection of mitochondrial superoxide production in live cells.
P Mukhopadhyay, M Rajesh, K Yoshihiro, G Hasko, P Pacher
Biochem Biophys Res Commun. 2007 Jun 22;358(1):203-8.

Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells.
K Yamatake, M Maeda, T Kadowaki, R Takii, T Tsukuba, T Ueno, E Komanami, S Yokota, K Yamamoto
Infect Immun. 2007 May;75(5):2090-100.

Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway.
A Csiszar, N Labinskyy, KE Smith, A Rivera, EN Bakker, H Jo, J Garnder, Z Orosz, Z Unqvari
Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):776-82.

Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy.
P Mukhopadhyay, M Rajesh, G Hasko, BJ Hawkins, M Madesh, P Pacher
Nat Protoc. 2007;2(9):2295-301.

Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins.
MC Messner, CJ Albert, FF Hsu, DA Ford
Chem Phys Lipids. 2006 Oct;144(1):34-44.

Metabolism of Myeloperoxidase-derived 2-Chlorohexadecanal.
KR Wildsmith, CJ Albert, DS Anbukumar, DA Ford
J Biol Chem. 2006 Jun 23;281(25):16849-60.

Myeloperoxidase-derived 2-chlorohexadecanal forms Schiff bases with primary amines of ethanolamine glycerophospholipids and lysine.
KR Wildsmith, CJ Albert, FF Hsu, JLF Kao, DA Ford
Chem Phys Lipids. 2006 Feb;139(2):157-70.

Regulation of endotoxin-induced proinflammatory activation in human coronary artery cells: expression of functional membrane-bound CD14 by human coronary artery smooth muscle cells.
LL Stoll, GM Denning, WG Li, JB Rice, AL Harrelson Romig SA, Gunnlaugsson ST, Miller FJ Jr, Weintraub NL
J Immunol. 2004 Jul 15;173(2):1336-43.

Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis.
C Bason, R Corrocher, C Lunardi, P Puccetti, O Olivieri, D Girelli, R Navone, R Beri, E Millo, A Margonato, N Martinelli, A Puccetti
Lancet. 2003 Dec 13;362(9400):1971-7.

Dehydroepiandrosterone, an adrenal androgen, increases human foam cell formation: a potentially pro-atherogenic effect.
MKC Ng, S Nakhla, A Baoutina, W Jessup, DJ Handelsman, DS Celermajer
J Am Coll Cardiol. 2003 Dec 3;42(11):1967-74.

Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery.
YC Liu, YC Lo, CW Huang, SN Wu
Biochem Pharmacol. 2003 Nov 15;66(10):2053-63.

Microarray analysis of nicotine-induced changes in gene expression in endothelial cells.
S Zhang, IN Day, S Ye
Physiol Genomics. 2001 Apr 27;5(4):187-92.

Repression of Smooth Muscle Differentiation by a Novel High Mobility Group Box-containing Protein, HMG2L1.
Zhou, J., Hu, G. and Wang, X.
J. Biol. Chem., Jul 2010; 285: 23177 - 23185.

Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications.
Nivison-Smith, L., Rnjak, J.
Acta Biomaterialia 6 (2): February 2010, 354-359.

Zhou, J., Hu, G. and Wang, X. (2011) Repression of Smooth Muscle Differentiation by a Novel High Mobility Group Box-containing Protein, HMG2L1. J. Biol. Chem. 285: 23177-23185.

**Synergistic drug combinations tend to improve therapeutically relevant selectivity.
Lehár J, Krueger AS, Avery W, Heilbut AM, Johansen LM, Price ER, Rickles RJ, Short GF 3rd, Staunton JE, Jin X, Lee MS, Zimmermann GR, Borisy AA.
Nat Biotechnol. 2009 Jul;27(7):659-66. Epub 2009 Jul 5.

Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding.
Zhou J, Blue EK, Hu G, Herring BP.
J Biol Chem. 2008 Dec 19;283(51):35383-92. Epub 2008 Oct 21.

**Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injury.
Malabanan KP, Kanellakis P, Bobik A, Khachigian LM.
Circ Res. 2008 Aug 15;103(4):378-87. Epub 2008 Jul 10.

Biogenesis of short intronic repeat 27-nucleotide small RNA from endothelial nitric-oxide synthase gene.
Zhang MX, Zhang C, Shen YH, Wang J, Li XN, Zhang Y, Coselli J, Wang XL.
J Biol Chem. 2008 May 23;283(21):14685-93. Epub 2008 Apr 3.

Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression.
YW Chen, ML Smith, M Sheets, S Ballaron, JM Trevillyan, SE Burke, T Rosenberg, C Henry, R Wagner, J Bauch, K Marsh, TA Fey, G Hsieh, D Gauvin, KW Mollison, GW Carter, SW Djuric
J Cardiovasc Pharmacol. 2007 Apr;49(4):228-35.

Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation.
Y Jin, EK Blue, PJ Gallagher
J Biol Chem. 2006 Dec 22;281(51):39033-40.

Matrix metalloproteinase expression in vein grafts: role of inflammatory mediators and extracellular signal-regulated kinases-1 and –2.
R Sharony, G Pintucci, PC Saunders, EA Grossi, FG Baumann, AC Galloway, P Mignatti
Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1651-9.

Thyroid hormone targets matrix Gla protein gene associated with vascular smooth muscle calcification.
Y Sato, R Nakamura, M Satoh, K Fujishita, S Mori, S Ishida, T Yamaguchi, K Inoue, T Nagao, Y Ohno
Circ Res. 2005 Sep 16;97(6):550-7.

Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase.
Y Gan, YH Shen, J Wang, X Wang, B Utama, XL Wang
J Biol Chem. 2005 Apr 22;280(16):16467-75.

A novel gene family induced by acute inflammation in endothelial cells.
K Warton, NC Foster, WA Gold, KK. Stanley
Gene. 2004 Nov 10;342(1):85-95.

Cigarette suppresses the expression of P4Halpha and vascular collagen production.
M Raveendran, D Senthil, B Utama, Y Shen, D Dudley, J Wang, Y Zhang, XL Wang
Biochem Biophys Res Commun. 2004 Oct 15;323(2):592-8.

Regulation of endotoxin-induced proinflammatory activation in human coronary artery cells: expression of functional membrane-bound CD14 by human coronary artery smooth muscle cells.
LL Stoll, GM Denning, WG Li, JB Rice, AL Harrelson Romig SA, Gunnlaugsson ST, Miller FJ Jr, Weintraub NL
J Immunol. 2004 Jul 15;173(2):1336-43.

Estradiol binding to maxi-K channels induces their down-regulation via proteasomal degradation.
VP Korovkina, AM Brainard, P Ismail, TJ Schmidt, SK England
J Biol Chem. 2004 Jan 9;279(2):1217-23.

Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery.
YC Liu, YC Lo, CW Huang, SN Wu
Biochem Pharmacol. 2003 Nov 15;66(10):2053-63.

Behavior of Nonselective Cation Channels and Large-Conductance Ca2+-Activated K+ Channels Induced by Dynamic Changes in Membrane Stretch in Cultured Smooth Muscle Cells of Human Coronary Artery.
SN Wu, PH Lin, KS Hsieh, YC Liu, HT Chiang
J Cardiovasc Electrophysiol. 2003 Jan;14(1):44-51.

** Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells.
Csiszar A, Labinskyy N, Jo H, Ballabh P, Ungvari Z
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H569-77. Epub 2008 Jun 6.

Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.
ED Karoly, Z Li, LA Dailey, X Hyseni, YC Huang
Environ Health Perspect. 2007 Apr;115(4):535-40.

Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells.
Z Li, X Hyseni, JD Carter, JM Soukup, LA Dailey, YT Huang
Am J Physiol Cell Physiol. 2006 Aug;291(2):C357-65.

Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells.
A Moldobaeva, LE Welsh-Servinsky, LA Shimoda, RS Stephens, AD Verin, TM Tuder, DB Pearse
Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L919-30.

S-nitrosoglutathione (SNOG) accumulates hypoxia inducible factor-l alpha in main pulmonary artery endothelial cells but not in micro pulmonary vessel endothelial cells.
S Fujiuchi, Y Yamazaki, Y Fujita, Y Nishigaki, A Taked, Y Yamamoto, T Fijikane, Y Shimizu, S Osanai, T Takahashi, K Kikuchi
Adv Exp Med Biol. 2006;580:63-71.

Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide.
BS Rayner, BJ Wu, M Raftery, R Stocker, PK Witting
J Biol Chem. 2005 Mar 18;280(11):9985-93.

Vasoactive factors in sickle cell disease: in vitro evidence for endothelin-1-mediated vasoconstriction.
S Ergul, CY Brunson, J Hutchinson, A Tawfik, A Kutlar, RC Webb, A Ergul
Am J Hematol. 2004 Jul;76(3):245-51.

Vanadyl Sulfate Inhibits NO Production via Threonine Phosphorylation of eNOS.
Z Li, JD Carter, LA Dailey, YT Huang
Environmental Health Perspectives, February 2004; 112(2):201-206.

Regulation of Bcl-xL expression in lung vascular smooth muscle.
YJ Suzuki, H Nagase, CM Wong, SV Kumar, V Jain, AM Park, RM Day
Am J Respir Cell Mol Biol. 2007 Jun;36(6):678-87.

TLR4 Activation and IL-6-Mediated Cross Talk between Adipocytes and Mononuclear Cells Synergistically Stimulate MMP-1 Expression.
Samuvel, D.J., Jin, J., Sundararaj, K.P., Li, Y., Zhang, X., Lopes-Virella, M.F. and Huang, Y.
Endocrinology December 2011, 152(12):4662–4671.

Chau, M.D.L., Gao, J., Yang, Q., Wu, Z. and Gromada, J. (2010) Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway. PNAS 107 (28) 12553–12558.

Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol.
B Spoto, F Fezza, G Parlongo, N Battista, E Sgro, V Gasperi, C Zoccali, M Maccarrone.
Biochimie. 2006 Dec;88(12):1889-97.

Gene expression in hair follicle dermal papilla cells after treatment with stanozolol.
Reiter M, Pfaffl MW, Schönfelder M, Meyer HH.
Biomark Insights. 2008 Dec 23;4:1-8.

trans-3,4'-Dimethyl-3-hydroxyflavanone, a hair growth enhancing active component, decreases active transforming growth factor beta2 (TGF-beta2) through control of urokinase-type plasminogen activator (uPA) on the surface of keratinocytes.
Sasajima M, Moriwaki S, Hotta M, Kitahara T, Takema Y.
Biol Pharm Bull. 2008 Mar;31(3):449-53.

Efficient immortalization of primary human cells by p16[INK4a]-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.
K Haga, S Ohno, T Yugawa, M Narisawa-Saito, M Fujita, M Sakamoto, DA Galloway, T Kiyono
Cancer Sci. 2007 Feb;98(2):147-54.

Differences in Expression of Specific Biomarkers Distinguish Human Beard from Scalp Dermal Papilla Cells.
SE Rutberg, ML Kolpak, JA Gourley, G Tan, JP Henry, D Shander
J Invest Dermatol. 2006 Dec;126(12):2583-95.

G Protein-coupled Receptor Kinase-2 Is a Novel Regulator of Collagen Synthesis in Adult Human Cardiac Fibroblasts.
D’Souza, K.M., Malhotra, R., Philip, J.L., Staron, M.L., Theccanat, T., Jeevanandam, V. and Akhter, S.A.
J Biol.Chem. 2011, 286 (17) 15507-15516.

Hemodynamic Modulation of Endocardial Thromboresistance.
NK Kapur, CB Deming, S Kapur, C Bian, HC Champion, JK Donahue, DA Kass, JJ Rade
Circulation. 2007 Jan 2;115(1):67-75.

Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts.
YJ Wang, R Sung, MW Lin, SN Wu
J Membr Biol. 2006;213(3):175-85.

Genetic and Epigenetic Inactivation of Extracellular Superoxide Dismutase Promotes an Invasive Phenotype in Human Lung Cancer by Disrupting ECM Homeostasis.
Teoh-Fitzgerald, M.L.T., Fitzgerald, M.P., Jensen, T.J., et al.
Mol. Cancer Res. 2012;10:40-51.

IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells.
Khalkhali-Ellis Z, Abbott DE, Bailey CM, Goossens W, Margaryan NV, Gluck SL, Reuveni M, Hendrix MJ.
J Cell Biochem. 2008 Sep 1;105(1):208-18.

Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner.
Bailey CM, Abbott DE, Margaryan NV, Khalkhali-Ellis Z, Hendrix MJ.
Mol Cell Biol. 2008 Apr;28(7):2235-43. Epub 2008 Jan 22.

Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells.
Postovit LM, Margaryan NV, Seftor EA, Kirschmann DA, Lipavsky A, Wheaton WW, Abbott DE, Seftor RE, Hendrix MJ.
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4329-34. Epub 2008 Mar 11.

The number of dysfunctional telomeres in a cell: one amplifies; more than one translocate.
Tusell L, Soler D, Agostini M, Pampalona J, Genescà A.
Cytogenet Genome Res. 2008;122(3-4):315-25. Epub 2009 Jan 30.

Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation.
Z Khalkhali-Ellis, MJ Hendrix
Cancer Res. 2007 Apr 15;67(8):3535-9.

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma.
A Ligresti, AS Moriello, K Starowicz, I Matias, S Pisanti, L De Petrocellis, C Laezza, G Portella, M Bifulco, V Di Marzo
J Pharmacol Exp Ther. 2006 Sep;318(3):1375-87.

Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension.
Kitao A, Sato Y, Sawada-Kitamura S, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Matsui O, Nakanuma Y
Am J Pathol. 2009 Aug;175(2):616-26. Epub 2009 Jul 16

ERM protein moesin is phosphorylated by advanced glycation end products and modulates endothelial permeability.
Guo X, Wang L, Chen B, Li Q, Wang J, Zhao M, Wu W, Zhu P, Huang X, Huang Q
Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H238-46. Epub 2009 Apr 24

**Actions and comparative efficacy of phosphatidylcholine formulation and isolated sodium deoxycholate for different cell types.
Gupta A, Lobocki C, Singh S, Robertson M, Akadiri OA, Malhotra G, Jackson IT.
Aesthetic Plast Surg. 2009 May;33(3):346-52. Epub 2009 Feb 7.

Endothelial Differentiation of Adipose-Derived Stem Cells: Effects of Endothelial Cell Growth Supplement and Shear Force
L. Fischer, S. McIlhenny, T. Tulenko, N. Golesorkhi, P. Zhang, R. Larson, J. Lombardi, I. Shapiro, P. DiMuzio.
Journal of Surgical Research 2009, 152:(1):157-166.

Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo.
A Martínez, E Zudaire, M Julian, TW Moody, F Cuttitta
Oncogene. 2005 Jun 9;24(25):4106-13.

Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis.
WJ Kim, JW Yockman, M Lee, JH Jeong, YH Kim, SW Kim
J Control Release. 2005 Aug 18;106(1-2):224-34.

Cocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2.
TP Kenny, CL Keen, P Jones, HJ Kung, HH Schmitz, M. Eric Gershwin
Exp Biol Med. 2004 Sep;229(8):765-71.

Vascular endothelial cell growth factor attenuates actions of transforming growth factor-beta in human endothelial cells.
K Yamauchi, Y Nishimura, S Shigematsu, Y Takeuchi, J Nakamura, T Aizawa, K Hashizume
J Biol Chem. 2004 Dec 31;279(53):55104-8.

An artificially designed pore-forming protein with anti-tumor effects.
HM Ellerby, S Lee, LM Ellerby, S Chen, T Kiyota, G del Rio, G Sugihara, Y Sun, DE Bredesen, W Arap, R Pasqualini
J Biol Chem. 2003 Sep 12;278(37):35311-6.

Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly.
J Wang, P Lou, R Lesniewski, J Henkin
Anticancer Drugs. 2003 Jan;14(1):13-9.

Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults.
KA Youdim, J McDonald, W Kalt, JA Joseph
J Nutr Biochem. 2002 May;13(5):282-288.

Human adipose tissue endothelial cells promote preadipocyte proliferation.
J Hutley, AC Herington, W Shurety, C Cheung, DA Vesey, DP Cameron, JB Prins
Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E1037-44.
 
Dexamethasone affects cytokine-mediated adhesion of HL-60 human promyelocytic leukemia cells to cultured dermal microvascular endothelial cells.
NA Patel, JA Patel, MF Stins, KS Kim, SL Chang
Clin Immunol. 2001 Jun;99(3):387-94.

Anti-cancer activity of targeted pro-apoptotic peptides.
HM Ellerby, W Arap, LM Ellerby, R Kain, R Andrusiak, GD Rio, S Krajewski, CR Lombardo, R Rao, E Ruoslahti, DE Bredesen, R Pasqualini
Nat Med. 1999 Sep;5(9):1032-8.

Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf
Wang, Y., Ono, Y., Ikeda, Y., Okamoto, S., Murata, M., Poncz, M. and Matsubara, Y.
Blood (ASH Annual Meeting Abstracts) 2011 118: Abstract 908.

Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
Takayama, N., Nishimura, S., Nakamura, S., Shimizu, T., Ohnishi, R., Endo, H., Yamaguchi, T., Otsu, M., Nishimura, K., Nakanishi, M., Sawaguchi, A., Nagai, R. Takahashi, K., Yamanaka, S., Nakauchi, H. and Eto, K.  J. Exp. Med., Dec 2010, 207: 2817 - 2830.

A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses.
Yamazaki, C.M., Kadoya, Y., Hozumi, K.
Biomaterials March 2010, 31 (7): 1925-1934.

Targeting of Integrin β1 and Kinesin 2{alpha} by MicroRNA 183.
Li, G., Luna, C., Qiu, J., Epstein, D.L. and Gonzalez, P.
J. Biol. Chem., Feb 2010; 285: 5461 - 5471.

Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.
Haferkamp S, Scurr LL, Becker TM, Frausto M, Kefford RF, Rizos H.
J Invest Dermatol. 2009 Aug;129(8):1983-91. Epub 2009 Feb 12.

Expression of recombinant human epidermal growth factor in Escherichia coli and characterization of its biological activity.
Abdull Razis AF, Ismail EN, Hambali Z, Abdullah MN, Ali AM, Mohd Lila MA.
Appl Biochem Biotechnol. 2008 Mar;144(3):249-61.

Twist promotes tumor cell growth through YB-1 expression.
Shiota M, Izumi H, Onitsuka T, Miyamoto N, Kashiwagi E, Kidani A, Yokomizo A, Naito S, Kohno K.
Cancer Res. 2008 Jan 1;68(1):98-105.

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors.
K Takahashi, K Tanabe, M Ohnuki, M Narita, T Ichisaka, K Tomoda, S Yamanaka
Cell. 2007 Nov 30; 131(5): 861-872.

Fibroblasts form a body-wide cellular network.
HM Langevin, CJ Cornbrooks, DJ Taatjes
Histochem Cell Biol. 2004 Jul;122(1):7-15.

The E1 Protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of the Viral Genome.
N. Egawa, T. Nakahara, S. Ohno., M. Narisawa-Saito, T. Yugawa, M. Fujita, K. Yamato, Y. Natori and T. Kiyono
J. Virol., Mar 2012; 86: 3276 - 3283.

Effect of green Coffea arabica L. seed oil on extracellular matrix components and water-channel expression in in vitro and ex vivo human skin models.
Velazquez Pereda Mdel C, Dieamant Gde C, Eberlin S, Nogueira C, Colombi D, Di Stasi LC, de Souza Queiroz ML.
J Cosmet Dermatol. 2009 Mar;8(1):56-62.

E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions.
M Perrais, X Chen, M Perez-Moreno, BM Gumbiner.
Mol Biol Cell. 2007 Jun;18(6):2013-25.

Regulation of Notch1 Gene Expression by p53 in Epithelial Cells.
T Yugawa, K Handa, M Narisawa-Saito, S Ohno, M Fujita, T Kiyono.
Mol Cell Biol. 2007 May;27(10):3732-42.

E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein.
K Handa, T Yugawa, M Narisawa-Saito, S Ohno, M Fujita, T Kiyono
J Virol. 2007 Feb;81(3):1379-89.

Efficient immortalization of primary human cells by p16[INK4a]-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.
K Haga, S Ohno, T Yugawa, M Narisawa-Saito, M Fujita, M Sakamoto, DA Galloway, T Kiyono
Cancer Sci. 2007 Feb;98(2):147-54.

HPV16 E6-mediated stabilization of ErbB2 in neoplastic transformation of human cervical keratinocytes.
Narisawa-Saito, K Handa, T Yugawa, S Ohno, M Fujita, T Kiyono
Oncogene. 2007 May 10;26(21):2988-96.

DNA methylation profiling of human chromosomes 6, 20 and 22.
F Eckhardt, J Lewin, R Cortese, VK Rakyan, J Attwood, M Burger, J Burton, TV Cox, R Davies, TA Down, C Haefliger, R Horton, K Howe, DK Jackson, J Kunde, C Koenig, J Liddle, D Niblett, T Otto, R Pettett, S Seemann, C Thompson, T West, J Rogers, A Olek, K Berlin, S Beck
Nat Genet. 2006 Dec;38(12):1378-85.

Epigenetic Regulation of the Cell Type-Specific Gene 14-3-3sigma.
MM Oshiro, BW Futscher, A Lisberg, RJ Wozniak, WT Klimecki, FE Domann, AE Cres
Neoplasia. 2005 Sep;7(9):799-808.

Epigenetic silencing of DSC3 is a common event in human breast cancer.
MM Oshiro, CJ Kim, RJ Wozniak, DJ Junk, JL Munoz-Rodriguez, JA Burr, M Fitzgerald, SC Pawar, AE Cress, FE Domann, BW Futscher
Breast Cancer Res. 2005;7(5):R669-80.

Application of genetically modified feeder cells for culture of keratinocytes.
T Kameda, T Sugiyama
Methods Mol Biol. 2005;289:29-38.

SLURP-2, a novel member of the human Ly-6 superfamily that is up-regulated in psoriasis vulgaris.
H Tsuji, K Okamoto, Y Matsuzaka, H Iizuka, G Tamiya, H Inoko
Genomics. 2003 Jan;81(1):26-33.

Dynamic alteration of human beta-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin.
WK Huh, T Oono, Y Shirafuji, H Akiyama, J Arata, M Sakaguchi, NH Huh, K Iwatsuki
J Mol Med. 2002 Oct;80(10):678-84.

Role for DNA methylation in the control of cell typespecific maspin expression.
BW Futscher, MM Oshiro, RJ Wozniak, N Holtan, CL Hanigan, H Duan, FE Domann
Nat Genet. 2002 Jun;31(2):175-9.

Mast cell chymase regulates dermal mast cell number in mice.
Y Tomimori, T Muto, H Fukami, K Saito, C Horikawa
Biochem Biophys Res Commun. 2002 Feb 8;290(5):1478-82.

Wild type and melanoma-associated mutant p16(IN4a) proteins do not oligomerize in vivo.
McKenzie H, Becker TM, Scurr LL, Kefford RF, Rizos H.
Pigment Cell Melanoma Res. 2009 Feb;22(1):131-3.

Effects of Coccoloba uvifera L. on UV-stimulated melanocytes.
Silveira JE, Pereda Mdel C, Eberlin S, Dieamant GC, Di Stasi LC.
Photodermatol Photoimmunol Photomed. 2008 Dec;24(6):308-13.

p16INK4a-induced senescence is disabled by melanoma-associated mutations.
Haferkamp S, Becker TM, Scurr LL, Kefford RF, Rizos H.
Aging Cell. 2008 Oct;7(5):733-45.

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
H Tanami, I Imoto, A Hirasawa, Y Yuki, I Sonoda, J Inoue, K Yasui, A Misawa-Furihata, Y Kawakami, J Inazawa
Oncogene. 2004 Nov 18;23(54):8796-804.

Comparative gene expression analysis between coronary arteries and internal mammary arteries identifies a role for the TES gene in endothelial cell functions relevant to coronary artery disease.
Archacki, S.R., Angheloiu, G., Moravec, C.S., Liu, H., Topo, E.J. and Wang, Q.K.
Human Molecular Genetics, 2011; 1–10 doi:10.1093/hmg/ddr574

Human Umbilical Artery Endothelial Cells (HUAEC)

Phosphomannose Isomerase Inhibitors Improve N-Glycosylation in Selected Phosphomannomutase-deficient Fibroblasts.
Sharma, V., Ichikawa, M., He, P., Bravo, Y., Dahl, R., Ng, B.G., Cosford, N.D.P. and Freeze, H.H.
J. Biol. Chem. 286 (45) 39431 - 39438. November 11, 2011.

Mannose Efflux from the Cells a Potential Source of Mannose in Blood.
Sharma, V. and Freeze, H.H.
J. Biol. Chem. 2011, 286 (12) 10193 - 10200.

Ridaforolimus (AP23573; MK-8669), a Potent mTOR Inhibitor, Has Broad Antitumor Activity and Can Be Optimally Administered Using Intermittent Dosing Regimens.
Rivera,V.M., Squillace, R.M., Miller, D., Berk, L., Wardwell, S.D., Ning, Y., Pollock, R., Narasimhan, N.I., Iuliucci, J.D., Wang, F. and Clackson T.
Mol. Cancer Ther. 2011,10 1059 - 1071.

Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NFκB Signaling Pathway.
Jane, E.P., Premkumar, D.R. and Pollack, I.F. 
Mol. Cancer Ther. 2011, 10: 198-208.

Plasminogen Activator Inhibitor-1 Regulates Myoendothelial Junction Formation.
Heberlein, K.R., Straub, A.C., Best, A.K., Greyson, M.A., Looft-Wilson, R.C., Sharma, P.R., Meher, A., Leitinger, N. and Isakson, B.E.
Circ. Res., Apr 2010; 106: 1092 - 1102.

Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications.
Nivison-Smith, L., Rnjak, J.
Acta Biomaterialia 6 (2): February 2010, 354-359.

Effects of antioxidants on glucose-induced oxidative stress and endoplasmic reticulum stress in endothelial cells.
Sheikh-Ali, M., Sultan, S., Alamir, A.R., Haas, M.J., Mooradian, A.D
Diabetes Research and Clinical Practice. February 2010, 87 (2) 161-166.

Mature interleukin-33 is produced by calpain-mediated cleavage in vivo.
Hayakawa M, Hayakawa H, Matsuyama Y, Tamemoto H, Okazaki H, Tominaga S.
Biochem Biophys Res Commun. 2009 Sep 11;387(1):218-22. Epub 2009 Jul 9.

The Kunitz-like modulatory protein haemangin is vital for hard tick blood-feeding success.
Islam MK, Tsuji N, Miyoshi T, Alim MA, Huang X, Hatta T, Fujisaki K.
PLoS Pathog. 2009 Jul;5(7):e1000497. Epub 2009 Jul 10.

Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6.
Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S.
J Biol Chem. 2009 Jun 26;284(26):17731-41. Epub 2009 Apr 22.

**p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.
Kim CS, Jung SB, Naqvi A, Hoffman TA, DeRicco J, Yamamori T, Cole MP, Jeon BH, Irani K
Circ Res. 2008 Dec 5;103(12):1441-50. Epub 2008 Nov 6.

**A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
Yamanaka M, Anada Y, Igarashi Y, Kihara A.
Biochem Biophys Res Commun. 2008 Oct 31;375(4):675-9. Epub 2008 Aug 26.

The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine.
Rocha FG, Sundback CA, Krebs NJ, Leach JK, Mooney DJ, Ashley SW, Vacanti JP, Whang EE.
Biomaterials. 2008 Jul;29(19):2884-90. Epub 2008 Apr 8.

Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress.
Syeda F, Tullis E, Slutsky AS, Zhang H
Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2769-74. Epub 2008 Apr 25

Stathmin, a microtubule regulatory protein, is associated with hypoxia-inducible factor-1alpha levels in human endometrial and endothelial cells.
Yoshie M, Miyajima E, Kyo S, Tamura K.
Endocrinology. 2009 May;150(5):2413-8. Epub 2009 Jan 29.

Cholesterol transport from liposomal delivery vehicles.
A Kheirolomoom, KW Ferrara.
Biomaterials. 2007 Oct;28(29):4311-20.

Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells.
K Igarashi, I Sakimoto, K Kataoka, K Ohta, M Miura
Exp Cell Res. 2007 Sep 10;313(15):3326-36.

Targeting neuropilin 1 as an antitumor strategy in lung cancer.
TM Hong, YL Chen, YY Wu, A Yuan, YC Chao, YC Chung, MH Wu, SC Yang, SH Pan, JY Shih, WK Chan, PC Yang
Clin Cancer Res. 2007 Aug 15;13(16):4759-68.

SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor.
MA Ali, H Choy, AA Habib, D Saha
Neoplasia. 2007 May;9(5):370-81.

Talc mediates angiostasis in malignant pleural effusions via endostatin induction.
N Najmunnisa, KA Mohammed, S Brown, Y Su, PS Sriram, B Moudgil, R Loddenkemper, VB Antony
Eur Respir J. 2007 Apr;29(4):761-9.

Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway.
A Csiszar, N Labinskyy, KE Smith, A Rivera, EN Bakker, H Jo, J Garnder, Z Orosz, Z Unqvari.
Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):776-82.

Chlamydia pneumoniae stimulates the proliferation of HUVEC through the induction of VEGF by THP-1.
CR Carratelli, R Paolillo, A Rizzo
Int Immunopharmacol. 2007 Mar;7(3):287-94.

In vivo electrogene transfer of interleukin-12 inhibits tumor growth and lymph node and lung metastases in mouse mammary carcinomas.
MA Shibata, Y Ito, J Morimoto, K Kusakabe, R Yoshinaka, Y Otsuki
J Gene Med. 2006 Mar;8(3):335-52.

Suppression of hyperglycemia-induced superoxide formation and endothelin-1 gene expression by carvedilol.
MH Horani, MJ Haas, AD Mooradian
Am J Ther. 2006 Jan-Feb;13(1):2-7.

Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells.
N Miho, T Ishida, N Kuwaba, M Ishida, K Shimote-Abe, K Tabuchi, T Oshima, M Yoshzumi, K Chayama
Cardiovasc Res. 2005 Nov 1;68(2):289-98.

Thrombin functions through its RGD sequence in a non-canonical conformation.
ME Papaconstantinou, CJ Carrell, AO Pineda, KM Bobofchak, FS Matthews, CS Flordellis, ME Maragoudakis, NE Tsopanoglou, E Di Cera
J Biol Chem. 2005 Aug 19;280(33):29393-6.

Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis.
YI Kawamura, R Kawashima, R Fukunaga, K Hirai, N Toyama-Sorimachi, M Tokuhara, T Shimizu, T Dohi
Cancer Res. 2005 Jul 15;65(14):6220-7.

PKC/MAPK signaling suppression by retinal pericyte conditioned medium prevents retinal endothelial cell proliferation.
T Kondo, K Hosoya, S Hori, M Tomi, S Ohtsuki, T Terasaki
J Cell Physiol. 2005 May;203(2):378-86.

Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure.
A Csiszar, KE Smith, A Koller, G Kaley, JG Edwards, Z Ungvari
Circulation. 2005 May 10;111(18):2364-72.

Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase.
Y Gan, YH Shen, J Wang, X Wang, B Utama, XL Wang
J Biol Chem. 2005 Apr 22;280(16):16467-75.

A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems.
R Takii, T Kadowaki, A Baba, T Tsukuba, K Yamamoto
Infect Immun. 2005 Feb;73(2):883-93.

Rapid adaptive down regulation of oxidative burst induced by high dextrose in human umbilical vein endothelial cells.
MH Horani, MJ Haas, AD Mooradian
Diabetes Res Clin Pract. 2004 Oct;66(1):7-12.

Development of a novel optical bionanosensor.
O Worsfold, C Toma, T Nishiya
Biosens Bioelectron. 2004 Jun 15;19(11):1505-11.

C-Reactive Protein Promotes Monocyte Chemoattractant Protein-1—Mediated Chemotaxis Through Upregulating CC Chemokine Receptor 2 Expression in Human Monocytes.
KH Han, KH Hong, JH Park, J Ko, DH Kang, KJ Choi, MK Hong, SW Park, SJ Park
Circulation. 2004 Jun 1;109(21):2566-71.

Selectivity of an oncolytic herpes simplex virus for cells expressing the DF3/MUC1 antigen.
H Kasuya, TM Pawlik, JT Mullen, JM Donahue, H Nakamura, S Chandrasekhar, H Kawasaki, E Choi, KK Tanabe
Cancer Res. 2004 Apr 1;64(7):2561-7.

Adiponectin suppresses proliferation and superoxide generatio.n and enhances eNOS activity in endothelial cells treated with oxidized LDL.
H Motoshima, X Wu, K Mahadev, BJ Goldstein
Biochem Biophys Res Commun. 2004 Mar 5;315(2):264-71.

Chlamydia pneumoniae stimulates proliferation of vascular smooth muscle cells through induction of endogenous heat shock protein 60.
S Hirono, E Dibrov, C Hurtado, A Kostenuk, R Ducas
Circ Res. 2003 Oct 17;93(8):710-6.

An artificially designed pore-forming protein with anti-tumor effects.
HM Ellerby, S Lee, LM Ellerby, S Chen, T Kiyota, G del Rio, G Sugihara, Y Sun, DE Bredesen, W Arap, R Pasqualini
J Biol Chem. 2003 Sep 12;278(37):35311-6.

LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytes.
KH Han, Y Chen, MK Chang, YC Han, JH Park, SR Green, A Boullier, O Quehenberger
J Lipid Res. 2003 Jul;44(7):1332-40.

Purification, gene cloning, gene expression, and mutants of Dps from the obligate anaerobe Porphyromonas gingivalis.
J Ueshima, M Shoji, DB Ratnayake, K Abe, S Yoshida, K Yamamoto, and K Nakayama
Infect Immun. 2003 Mar;71(3):1170-8.

Plasmin-mediated proteolysis of vascular endothelial cell heparin releasable tissue factor pathway inhibitor.
Y Li, FA Spencer, RC Becker
J Thromb Thrombolysis. 2003 Feb;15(1):19-23.

Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly.
J Wang, P Lou, R Lesniewski, J Henkin
Anticancer Drugs. 2003 Jan;14(1):13-9.

Application of Toxicogenomic Analysis to Risk Assessment of Delayed Long-Term Effects of Multiple Chemicals, Including Endocrine Disruptors in Human Fetuses.
C Mori, M Komiyama, T Adachi, K Sakurai, D Nishimura, K Takashima, E Todaka
EHP Toxicogenomics. 2003 Jan;111(1T):7-13.

Regulation of herpes simplex virus 1 replication using tumor-associated promoters.
JT Mullen, H Kasuya, SS Yoon, NM Carroll, TM Pawlik, S Chandrasekhar, H Nakamura, JM Donahue, KK Tanabe
Ann Surg. 2002 Oct;236(4):502-12; discussion 512-3.

Sickle erythrocyte adherence to endothelium at low shear: role of shear stress in propagation of vaso-occlusion.
RA Montes, JR Eckman, LL Hsu, TM Wick
Am J Hematol. 2002 Jul;70(3):216-27.

Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia.
S Sato, N Ouellet, I Pelletier, M Simard, A Rancourt, MG Bergeron
J Immunol. 2002 Feb 15;168(4):1813-22.

Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells.
G Srikrishna, K Panneerselvam, V Westphal, V Abraham, A Varki, HH Freeze
J Immunol. 2001 Apr 1;166(7):4678-88.

A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses.
G Srikrishna, DK Toomre, A Manzi, K Panneerselvam, HH Freeze, A Varki, NM Varki
J Immunol. 2001 Jan 1;166(1):624-32.

An IgG antiprothrombin antibody enhances prothrombin binding to damaged endothelial cells and shortens plasma coagulation times.
Y Zhao, R Rumold, M Zhu, D Zhou, AE Ahmed, DT Le, BH Hagn, VL Woods Jr., PP Chen
Arthritis Rheum. 1999 Oct;42(10):2132-8.

Publications that utilize Cell Applications, Inc.’s Animal Cells

BOVINE

Bovine Aortic Endothelial Cells (BAOEC)

Suppression of Gα_s Synthesis by Simvastatin Treatment of Vascular Endothelial Cells.
Kou, R., Shiroto, T., Sartoretto, J.L. and Michel, T.
J. Biol. Chem. 287 (4) 2643–2651. January 20, 2012.

N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase.
Hou, H., Hammock, B.D., Su, K., Morisseau, C., Kou, Y.R., Imaoka, S., Oguro, A., Shyue, S., Zhao, J. and Lee, T.
Cardiovascular Research (2012) 93, 120-129.

Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation.
Kim, J., Jang, H., Martinez-Lemus, L.A., and Sowers, J.R.
Am. J. Physiol. Endocrinol. Metab. 302: E201–E208, 2012.

Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling.
Su KH, Tsai JY, Kou YR, Chiang AN, Hsiao SH, Wu YL, Hou HH, Pan CC, Shyue SK, Lee TS
Cardiovasc Res. 2009 Jun 1;82(3):468-75. Epub 2009 Mar 23.

Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.
Kou R, Sartoretto J, Michel T.
J Biol Chem. 2009 May 29;284(22):14734-43. Epub 2009 Mar 30.

Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation.
Meijering BD, Juffermans LJ, van Wamel A, Henning RH, Zuhorn IS, Emmer M, Versteilen AM, Paulus WJ, van Gilst WH, Kooiman K, de Jong N, Musters RJ, Deelman LE, Kamp O.
Circ Res. 2009 Mar 13;104(5):679-87. Epub 2009 Jan 22.

Salt inactivates endothelial nitric oxide synthase in endothelial cells.
Li J, White J, Guo L, Zhao X, Wang J, Smart EJ, Li XA.
J Nutr. 2009 Mar;139(3):447-51. Epub 2009 Jan 28.

Metabolism of the tumor angiogenesis inhibitor 4-(N-(S-Glutathionylacetyl)amino)phenylarsonous acid.
Dilda PJ, Ramsay EE, Corti A, Pompella A, Hogg PJ.
J Biol Chem. 2008 Dec 19;283(51):35428-34. Epub 2008 Aug 23.

LDL protein nitration: implication for LDL protein unfolding.
Hamilton RT, Asatryan L, Nilsen JT, Isas JM, Gallaher TK, Sawamura T, Hsiai TK.
Arch Biochem Biophys. 2008 Nov 1;479(1):1-14. Epub 2008 Aug 7.

Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion.
Chen H, Lin AS, Li Y, Reiter CE, Ver MR, Quon MJ.
J Biol Chem. 2008 Oct 24;283(43):29228-38. Epub 2008 Aug 21.

Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity.
Matsunaga T, Endo S, Maeda S, Ishikura S, Tajima K, Tanaka N, Nakamura KT, Imamura Y, Hara A.
Arch Biochem Biophys. 2008 Sep 15;477(2):339-47. Epub 2008 Jun 7.

Adiponectin protects against angiotensin II or tumor necrosis factor alpha-induced endothelial cell monolayer hyperpermeability: role of cAMP/PKA signaling.
Xu SQ, Mahadev K, Wu X, Fuchsel L, Donnelly S, Scalia RG, Goldstein BJ.
Arterioscler Thromb Vasc Biol. 2008 May;28(5):899-905. Epub 2008 Feb 21.

Atrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium.
Chen H, Levine YC, Golan DE, Michel T, Lin AJ.
J Biol Chem. 2008 Feb 15;283(7):4439-47. Epub 2007 Dec 12.

Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidant.
Mowbray AL, Kang DH, Rhee SG, Kang SW, Jo H.
J Biol Chem. 2008 Jan 18;283(3):1622-7. Epub 2007 Nov 16.

Remodeling of Endothelial Cell Nucleus Exposed to Three Different Mechanical Stimuli
Ohasi T, Hanamura K, Azuma D, Sakamoto N, Sato M.
Journal of Biomechanical Science and Engineering 3(2):63-74, 2008.

Plasma treatment of mammalian vascular cells: a quantitative description
IE Kieft et al.
IEEE transactions on plasma science, 2005, vol. 33 (2), no 2 (14 ref.), pp. 771-775

Cell patterning without chemical surface modification : Cell-cell interactions between printed bovine aortic endothelial cells (BAEC) on a homogeneous cell-adherent hydrogel
CY Chen et al. Applied Surface Science 2006, vol. 252, no24, pp. 8641-8645

TNF-alpha potentiates protein-tyrosine nitration through activation of NADPH oxidase and eNOS localized in membrane rafts and caveolae of bovine aortic endothelial cells
B Yang & V Rizzo
Am J Physiol Heart Circ Physiol 292: H954-H962, 2007.

Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury.
N Gousseva et al.
J Cell Biochem. 2001;81(3):523-34.

Mechanism of Selectivity of an Angiogenesis Inhibitor From Screening a Genome-Wide Set of Saccharomyces cerevisiae Deletion Strains
PJ Dilda et al.
JNCI Journal of the National Cancer Institute 2005 97(20):1539-1547

Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production
MA Potenza, et al.
Am J Physiol Heart Circ Physiol 289: H813-H822, 2005.

Dihydrotestosterone Promotes VCAM-1 Expression in Male Human Endothelial Cells via a NF-kB Dependent Pathway.
AK Death, KC McGrath, MA Sader, S Nakhla, W Jessup, DJ Handelsman, DS Celermajer
 Endocrinology. 2004 Apr;145(4):1889-97. Epub 2003 Dec 18.

Kruppel-like factor 4 regulates endothelial inflammation.
A Hamik, Z Lin, A Kumar, M Balcells, S Sinha, J Katz, MW Feinberg, RE Gerzsten, ER Edelman, MK Jain
J Biol Chem. 2007 May 4;282(18):13769-79. Epub 2007 Mar 5.

Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway.
R Ouedraogo, X Wu, SQ Xu, L Fuchsel, H Motoshima, K Mahadev, K Hough, R Scalia, BJ Goldstein
Diabetes. 2006 Jun;55(6):1840-6.

Clostridium botulinum serotype D neurotoxin and toxin complex bind to bovine aortic endothelial cells via sialic acid.
Yoneyama T, Miyata K, Chikai T, Mikami A, Suzuki T, Hasegawa K, Ikeda T, Watanabe T, Ohyama T, Niwa K.
FEMS Immunol Med Microbiol. 2008 Dec;54(3):290-8. Epub 2008 Sep 17.

Effect of serum concentration on adhesion of monocytic THP-1 cells onto cultured EC monolayer and EC-SMC co-culture.
Fan LJ, Karino T.
J Zhejiang Univ Sci B. 2008 Aug;9(8):623-9.

Flow-dependent accumulation of LDL in co-cultures of endothelial and smooth muscle cells in the presence of filtration flow through the cell layer.
Sakai J, Karino T, Niwa K.
Clin Hemorheol Microcirc. 2008;38(4):245-56.

Integrated MEMS structures and CMOS circuits for bioelectronic interface with single cells
N Reeves, et al.
ISCAS'04. Proceedings of the 2004 International Symposium on Circuits and Systems, 2004. Vol. 3 (III): 673-6, Vol. 3.

Cell-lab on a chip: a CMOS-based microsystem for culturing and monitoring cells
Y Liu et al.
Engineering in Medicine and Biology Society, 2004. EMBC 2004 Vol. 1: 2534- 2537, Vol.4

CMOS contact imager for monitoring cultured cells
H Ji, et al.
3491- 3494 Vol. 4 2005. IEEE International Symposium on Circuits and Systems

Improved arterial wall model by coculturing vascular endothelial and smooth muscle cells
K Niwa, et al.
In Vitro Cellular & Developmental Biology-Animal, 2007 43:1:17-20

Blood–brain barrier invasion by Cryptococcus neoformans is enhanced by functional interactions with plasmin.
Stie, J. and Fox, D.
Microbiology (2012) 158, 240–258.

Effects of Immunomodulatory and Organism-Associated Molecules on the Permeability of an in vitro Blood-Brain Barrier Model to Amphotericin B and Fluconazole.
Pyrgos, V., Mickiene, D., Sein, T., Cotton, M., Fransesconi, A., Mizrahi, I., Donoghue, M., Bundrant, N., Kim, S., Hardwick, M., Shoham, S. and Walsh, T.J.
Antimicrob. Agents Chemother., Mar 2010; 54: 1305 - 1310.

Mechanisms of C-reactive protein-induced blood-brain barrier disruption.
Kuhlmann CR, Librizzi L, Closhen D, Pflanzner T, Lessmann V, Pietrzik CU, de Curtis M, Luhmann HJ.
Stroke. 2009 Apr;40(4):1458-66. Epub 2009 Feb 26.

Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein.
Kandimalla KK, Scott OG, Fulzele S, Davidson MW, Poduslo JF.
PLoS One. 2009;4(2):e4627. Epub 2009 Feb 27.

Quaternary Ammonium beta-Cyclodextrin Nanoparticles for Enhancing Doxorubicin Permeability across the in vitro Blood-Brain Barrier.
Gil ES, Li J, Xiao H, Lowe TL.
Biomacromolecules. 2009 Feb 13. [Epub ahead of print]

Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro.
Kuhlmann CR, Gerigk M, Bender B, Closhen D, Lessmann V, Luhmann HJ.
Life Sci. 2008 Jun 20;82(25-26):1281-7. Epub 2008 May 9.

Stealth dendrimers for drug delivery: correlation between PEGylation, cytocompatibility, and drug payload.
Yang H, Lopina ST, DiPersio LP, Schmidt SP.
J Mater Sci Mater Med. 2008 May;19(5):1991-7. Epub 2007 Oct 19.

Bach1 Functions as a Hypoxia-inducible Repressor for the Heme Oxygenase-1 Gene in Human Cells
T Kitamuro, et al.
J. Biol. Chem., Vol. 278, Issue 11, 9125-9133, March 14, 2003

Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress
OC Colgan, et al.
Am J Physiol Heart Circ Physiol 292: H3190-H3197, 2007

**Vascular cell viability on polyvinyl alcohol hydrogels modified with water-soluble and -insoluble chitosan.
Mathews DT, Birney YA, Cahill PA, McGuinness GB.
J Biomed Mater Res B Appl Biomater. 2008 Feb;84(2):531-40.

Diabetes-induced coronary vascular dysfunction involves increased arginase activity.
Romero MJ, Platt DH, Tawfik HE, Labazi M, El-Remessy AB, Bartoli M, Caldwell RB, Caldwell RW.
Circ Res. 2008 Jan 4;102(1):95-102. Epub 2007 Oct 25.

Cocaine-mediated apoptosis in bovine coronary artery endothelial cells: role of nitric oxide.
J. He, et al.
Journal of Pharmacology and Experimental Therapeutics, Vol. 298, Issue 1, 180-187, July 2001

Surface modifications of photocrosslinked biodegradable elastomers and their influence on smooth muscle cell adhesion and proliferation.
Ilagan BG, Amsden BG.
Acta Biomater. 2009 Mar 27. [Epub ahead of print]

Virulence attributes of Histophilus somni with a deletion mutation in the ibpA gene.
Hoshinoo K, Sasaki K, Tanaka A, Corbeil LB, Tagawa Y.
Microb Pathog. 2009 May;46(5):273-82. Epub 2009 Mar 6.

Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line.
Krishnaswamy N, Danyod G, Chapdelaine P, Fortier MA.
Endocrinology. 2009 Feb;150(2):897-905. Epub 2008 Oct 1.

Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells
PK Tithof et al.
Reprod Biol Endocrinol. April 25. 2007; 5: 16.

Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms.
Day, R.M., Lee, Y.H., Han, L., Kim, Y. and Feng, Y.
Am J Physiol Lung Cell Mol Physiol, 301: L772 - L781. Nov 2011.

Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells.
Peltz A, Sherwani SI, Kotha SR, Mazerik JN, O'Connor Butler ES, Kuppusamy ML, Hagele T, Magalang UJ, Kuppusamy P, Marsh CB, Parinandi NL.
Int J Toxicol. 2009 May-Jun;28(3):190-206.

Induction of drug-metabolizing enzymes by phenobarbital in layered co-culture of a human liver cell line and endothelial cells.
Ohno M, Motojima K, Okano T, Taniguchi A.
Biol Pharm Bull. 2009 May;32(5):813-7.

Maturation of the extracellular matrix and cell adhesion molecules in layered co-cultures of HepG2 and endothelial cells.
Ohno M, Motojima K, Okano T, Taniguchi A.
J Biochem. 2009 May;145(5):591-7. Epub 2009 Jan 27.

Up-regulation of drug-metabolizing enzyme genes in layered co-culture of a human liver cell line and endothelial cells.
Ohno M, Motojima K, Okano T, Taniguchi A.
Tissue Eng Part A. 2008 Nov;14(11):1861-9.

Characterization of the bovine angiotensin converting enzyme promoter: essential roles of Egr-1, ATF-2 and Ets-1 in the regulation by phorbol ester.
Mungunsukh O, Marquez AP, Lee YH, Thiel G, Day RM.
Gene. 2008 Sep 15;421(1-2):81-8. Epub 2008 Jun 7.

Regulation of Circulating Progenitor Cells in Left Ventricular Dysfunction
Boilson, B.A., Larsen, K., Harbuzariu, A., Delacroix, S., Korinek, J., Froehlich, H., Bailey, K.R., Scott, C.G., Shapiro, B.P., Boerrigter, G., Chen, H.H., Redfield, M.M., Burnett, Jr, J.C. and Simari, R.D.
Circ Heart Fail, Sep 2010; 3: 635 - 642.

Canine Chondrocytes (CnC)

Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity.
Remsberg CM, Yáñez JA, Ohgami Y, Vega-Villa KR, Rimando AM, Davies NM.
Phytother Res. 2008 Feb;22(2):169-79.

Selective neointimal gene transfer in an avian model of vascular injury.
R. Wang et al.
Atherosclerosis. 1999 Sep;146(1):71-82.

Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation.
Kim YT, Lee HJ, Lee SW, Kim JY, Wi HC, Park SJ, Bae SJ, Kang HJ.
Xenotransplantation. 2008 Feb;15(1):27-35.

Analysis of Voltage-Gated Potassium Channel [beta]1 Subunits in the Porcine Neonatal Ductus Arteriosus.
Pediatric Research. 59(2):167-174, February 2006.
E. Hayama, et al.

Perivascular endothelial implants inhibit intimal hyperplasia in a model of arteriovenous fistulae: a safety and efficacy study in the pig.
Journal of Vascular Research 2002;39:524-533
HM Nugent, et al.

Characterization of porcine circulating progenitor cells: toward a functional endothelium.
Allen J, Khan S, Serrano MC, Ameer G.
Tissue Eng Part A. 2008 Jan;14(1):183-94.

Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries. 
Journal of Vascular Surgery, Volume 44, Issue 4, Pages 853-862
W. Zhou, et al.

Long-term viability of coronary artery smooth muscle cells on poly(L-lactide-co-epsilon-caprolactone) nanofibrous scaffold indicates its potential for blood vessel tissue engineering.
Dong Y, Yong T, Liao S, Chan CK, Ramakrishna S.
J R Soc Interface. 2008 Sep 6;5(26):1109-18.

APD791, a Novel 5-HT2A Receptor Antagonist: Pharmacological Profile, Pharmacokinetics, Platelet and Vascular Biology.
Adams JW, Ramirez J, Shi Y, Thomsen W, Frazer J, Morgan M, Edwards JE, Chen W, Teegarden BR, Xiong Y, Al-Shamma H, Behan DP, Connolly DT.
J Pharmacol Exp Ther. 2009 Jul 23. [Epub ahead of print]

Probucol Protects Against Smooth Muscle Cell Proliferation by Upregulating Heme Oxygenase-1
YM Deng et al.
Circulation. 2004;110:1855-1860

Intermedin induces loss of coronary microvascular endothelial barrier via derangement of actin cytoskeleton: role of RhoA and Rac1.
Aslam, M., Gündüz, D., Schuler, D., Li, L., Sharifpanah, F., Sedding, D., Piper, H.M. and Noll, T.
Cardiovasc Res. 92: 276 - 286. Nov 2011.

Hyaluronan Mixed Esters of Butyric and Retinoic Acid Affording Myocardial Survival and Repair without Stem Cell Transplantation.
Lionetti, V., Cantoni, S., Cavallini, C., Bianchi, F., Valente, S., Frascari, I., Olivi, E., Aquaro, G.D., Bonavita, F., Scarlata, I., Maioli, M., Vaccari, V., Tassinari, R., Bartoli, A., Recchia, F.A., Pasquinelli, G. and Ventura, C.
J. Biol. Chem., Mar 2010; 285: 9949 - 9961.

MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.
Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, Lu Q, Deitch EA, Huo Y, Delphin ES, Zhang C.
 Circ Res. 2009 Jul 17;105(2):158-66. Epub 2009 Jun 18.

Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophy.
Makino A, Suarez J, Wang H, Belke DD, Scott BT, Dillmann WH.
Endocrinology. 2009 Apr;150(4):2008-15. Epub 2008 Dec 12.

*A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia.
Liu X, Cheng Y, Zhang S, Lin Y, Yang J, Zhang C.
Circ Res. 2009 Feb 27;104(4):476-87. Epub 2009 Jan 15.

Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles.
Sorensen CM, Salomonsson M, Braunstein TH, Nielsen MS, Holstein-Rathlou NH.
Am J Physiol Regul Integr Comp Physiol. 2008 Sep;295(3):R840-7. Epub 2008 Jul 9.

Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice.
Makino A, Platoshyn O, Suarez J, Yuan JX, Dillmann WH.
 Am J Physiol Cell Physiol. 2008 Jul;295(1):C221-30. Epub 2008 May 7.

Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury.
Yao EH, Fukuda N, Ueno T, Matsuda H, Matsumoto K, Nagase H, Matsumoto Y, Takasaka A, Serie K, Sugiyama H, Sawamura T.
Hypertension. 2008 Jul;52(1):86-92. Epub 2008 Jun 2.

Hyaluronic acid cues for functional endothelialization of vascular constructs.
Ibrahim S, Ramamurthi A.
 J Tissue Eng Regen Med. 2008 Jan;2(1):22-32.

Surface-directed differentiation of embryonic stem cells
E Hanley, JL Lauer, BK Micales, GE Lyons.
Applied Physics Letters 92, 193902. 2008.

Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury.
N Gousseva et al.
J Cell Biochem. 2001;81(3):523-34.

Fibronectin is an important regulator of flow-induced vascular remodeling.
Chiang HY, Korshunov VA, Serour A, Shi F, Sottile J.
Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1074-9. Epub 2009 Apr 30.

Impact of endothelial cells and mechanical conditioning on smooth muscle cell extracellular matrix production and differentiation.
Bulick AS, Muñoz-Pinto DJ, Qu X, Mani M, Cristancho D, Urban M, Hahn MS.
Tissue Eng Part A. 2009 Apr;15(4):815-25.

Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells.
Kothapalli CR, Taylor PM, Smolenski RT, Yacoub MH, Ramamurthi A.
Tissue Eng Part A. 2009 Mar;15(3):501-11.

*A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia.
Liu X, Cheng Y, Zhang S, Lin Y, Yang J, Zhang C.
Circ Res. 2009 Feb 27;104(4):476-87. Epub 2009 Jan 15.

Copper nanoparticle cues for biomimetic cellular assembly of crosslinked elastin fibers.
Kothapalli CR, Ramamurthi A.
Acta Biomater. 2009 Feb;5(2):541-53. Epub 2008 Sep 21.

Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells.
Alexis JD, Wang N, Che W, Lerner-Marmarosh N, Sahni A, Korshunov VA, Zou Y, Ding B, Yan C, Berk BC, Abe J.
Circ Res. 2009 Jan 2;104(1):69-78. Epub 2008 Nov 20.

Biomimetic regeneration of elastin matrices using hyaluronan and copper ion cues.
Kothapalli CR, Ramamurthi A.
Tissue Eng Part A. 2009 Jan;15(1):103-13.

*Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injury.
Malabanan KP, Kanellakis P, Bobik A, Khachigian LM.
Circ Res. 2008 Aug 15;103(4):378-87. Epub 2008 Jul 10.

Imatinib mesilate inhibits neointimal hyperplasia via growth inhibition of vascular smooth muscle cells in a rat model of balloon injury.
Makiyama Y, Toba K, Kato K, Hirono S, Ozawa T, Saigawa T, Minagawa S, Isoda M, Asami F, Ikarashi N, Oda M, Moriyama M, Higashimura M, Kitajima T, Otaki K, Aizawa Y.
Tohoku J Exp Med. 2008 Aug;215(4):299-306.

Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover.
Shi F, Sottile J.
J Cell Sci. 2008 Jul 15;121(Pt 14):2360-71. Epub 2008 Jun 24.

Attenuation of maitotoxin-induced cytotoxicity in rat aortic smooth muscle cells by inhibitors of Na+/Ca2+ exchange, and calpain activation.
Frew R, Wang Y, Weiss TM, Nelson P, Sawyer TW.
Toxicon. 2008 Jun 15;51(8):1400-8. Epub 2008 Mar 15.

Anti-thrombotic and vascular effects of AR246686, a novel 5-HT2A receptor antagonist.
Adams JW, Ramirez J, Ortuno D, Shi Y, Thomsen W, Richman JG, Morgan M, Dosa P, Teegarden BR, Al-Shamma H, Behan DP, Connolly DT.
Eur J Pharmacol. 2008 May 31;586(1-3):234-43. Epub 2007 Dec 3.

Inhibition of cardiovascular cell proliferation by angiotensin receptor blockers: are all molecules the same?
Benson SC, Iguchi R, Ho CI, Yamamoto K, Kurtz TW.
J Hypertens. 2008 May;26(5):973-80.

Multipotent adult progenitor cells sustain function of ischemic limbs in mice.
Aranguren XL, McCue JD, Hendrickx B, Zhu XH, Du F, Chen E, Pelacho B, Peñuelas I, Abizanda G, Uriz M, Frommer SA, Ross JJ, Schroeder BA, Seaborn MS, Adney JR, Hagenbrock J, Harris NH, Zhang Y, Zhang X, Nelson-Holte MH, Jiang Y, Billiau AD, Chen W, Prósper F, Verfaillie CM, Luttun A.
J Clin Invest. 2008 Feb;118(2):505-14.

Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion.
Taite LJ, Yang P, Jun HW, West JL.
J Biomed Mater Res B Appl Biomater. 2008 Jan;84(1):108-16.

Nerve growth factor activation of Erk-1 and Erk-2 induces matrix metalloproteinase-9 expression in vascular smooth muscle cells.
KMF Khan et al.
J Biol Chem. 2002 Jan 18;277(3):2353-9. Epub 2001 Nov 6.

Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats.
P Andrade-Gordon et al.
J Pharmacol Exp Ther. 2001 Jul;298(1):34-42.

Localized delivery of nitric oxide from hydrogels inhibits neointima formation in a rat carotid balloon injury model.
EA Lipke & JL West
Acta Biomater. 2005 Nov;1(6):597-606. Epub 2005 Sep 30.

New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury.
FS Santiago et al.
Nat Med. 1999 Nov;5(11):1264-9.

Thyroid hormone targets matrix Gla protein gene associated with vascular smooth muscle calcification.
Y Sato et al.
Circ Res. 2005 Sep 16;97(6):550-7. Epub 2005 Aug 11.

Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation.
E Ogru et al.
Ann N Y Acad Sci. 2004 Dec;1031:405-11.

GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.
LM Khachigian et al.
Circ Res. 1999 Jun 11;84(11):1258-67.

Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2.
FS Santiago et al.
J Biol Chem. 2001 Nov 2;276(44):41143-9. Epub 2001 Aug 3.

PDGF-BB induces vascular smooth muscle cell expression of high molecular weight FGF-2, which accumulates in the nucleus.
G Pintucci, et al.
J Cell Biochem. 2005 Aug 15;95(6):1292-300.

Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr-1/NGFI-A-dependent.
FS Santiago et al.
Am J Pathol. 1999 Sep;155(3):897-905.

Fibronectin Matrix Turnover Occurs through a Caveolin-1–dependent Process
J Sottile & J Chandler
Mol Biol Cell. 2005 February; 16(2): 757–768.

C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase 1/2.
D Walcher et al.
Circ Res. 2006 Nov 24;99(11):1181-7. Epub 2006 Oct 26

Expression of coxsackievirus and adenovirus receptor in neointima of the rat carotid artery
A Nasuno et al.
Cardiovascular Pathology Volume 13, Issue 2, March-April 2004, Pages 79-84

Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia
H.V. Danesh-Meyer, N.M. Kerr, J. Zhang, E.K. Eady, S.J. O'Carroll, L.F.B. Nicholson, C.S. Johnson, and C.R. Green
Brain, Feb 2012; 135: 506 - 520.

Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain.
Zhao P, Barr TP, Hou Q, Dib-Hajj SD, Black JA, Albrecht PJ, Petersen K, Eisenberg E, Wymer JP, Rice FL, Waxman SG.
Pain. 2008 Sep 30;139(1):90-105. Epub 2008 Apr 28.

Hyperoxia-induced NF-kappaB activation occurs via a maturationally sensitive atypical pathway.
Wright CJ, Zhuang T, La P, Yang G, Dennery PA.
Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L296-306. Epub 2008 Dec 12.

Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection
Zhang, T., Li, Z., Dang, H., Chen, R., Liaw, C., Tran, T., Boatman, P.D., Connolly, D.T. and Adams, J.W.
Am. J. Physiol. Heart Circ. Physiol. 302: H299 - H311, 2012.

Differences in Effects on Myocardium and Mitochondria by Angiogenic Inhibitors Suggest Separate Mechanisms of Cardiotoxicity.
French, K.J., Coatney, R.W., Renninger, J.P., Hu, C.X., Gales, T.L., Zhao, S., Storck, L.M., Davis, C.B., McSurdy-Freed, J., Chen, E. and Frazier, K.S.
Toxicol Pathol. Aug 2010; 38: 691 - 702.

Hyaluronan mixed esters of butyric and retinoic acid affording myocardial survival and repair without stem cell transplantation.
Lionetti V, Cantoni S, Cavallini C, Bianchi F, Valente S, Frascari I, Olivi E, Aquaro GD, Bonavita F, Scarlata I, Maioli M, Vaccari V, Tassinari R, Bartoli A, Recchia FA, Pasquinelli G, Ventura C.
J Biol Chem. 2010 Mar 26;285(13):9949-61. Epub 2010 Jan 2.

Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles.
Sun C, Fang C, Stephen Z, Veiseh O, Hansen S, Lee D, Ellenbogen RG, Olson J, Zhang M.
Nanomed. 2008 Aug;3(4):495-505.

Oxygen availability limits renal NADPH-dependent superoxide production.
Y Chen et al.
Am J Physiol Renal Physiol. 2005 Oct;289(4):F749-53. Epub 2005 Jun 7.

Effect of thioridazine on gap junction intercellular communication in connexin 43-expressing cells.
DF Matesic et al.
Cell Biol Toxicol. 2006 Jul;22(4):257-68. Epub 2006 May 9.