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Rat
Mesenchymal Stem Cells (RMSC) are isolated from rat
bone marrow and are cryopreserved at second passage.
RMSC can be cultured and propagated 10 population
doublings. In addition to supporting hematopoietic
cells1, mesenchymal stem cells can be
induced to differentiate and express the traits of
multiple cell lineages, including connective tissue
(such as bone, cartilage, and fat)2,3,4,5
and neural cells6,7. The multipotent
potential of RMSC in vitro provides new
avenues for cell-based therapy, and studies have
demonstrated the use of 3-D scaffolds for tissue
engineering using RMSC8,9,10.
1.
Rochefort, GY et al., Stem Cells 24(10):2202 (2006).
2.
Yeon Lim, J et al., Exp Neurol. 199(2):416 (2006).
3.
Sergeeva, NS et al., Bull Exp Biol Med. 141(4):530
(2006).
4.
Backesjo, CM et al., J Bone Miner Res. 21(7):993
(2006).
5.
Want, Q et al., Biochem Biophys Res Commun.
347(1):117 (2006).
6.
Yang, LY et al., Biomed Environ Sci. 19(5):329
(2006).
7.
Tohill, M et al., Neurosci Lett. 362(3):200
(2004).
8.
Li, M et al., Conf Proc IEEE Eng Med Biol Soc
6(1):5858 (2005).
9.
Claase, MB et al., J Mater Sci Mater Med.
(2007).
10. Coleman, RM et al., Biomaterials. 28(12):2077
(2007).
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