| Cat.# |
CB5792
|
| Size |
136
µg / 200
ml |
| Isotype:
|
rabbit polyclonal
IgG
|
| Epitope: |
E.
coli-expressed
expressed cytoplasmic domain of human VEGF receptor-3.
|
|
Species
&
specficity:
|
Anti-VEGFR3
specifically
detects over-expressed levels of human VEGF receptor-3.
This antibody does not cross-react with other VEGFR-family
members.
|
| Storage: |
Store
at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw
cycles.
|
| MW:
|
198
kDa
|
|
Application:
|
IHC
(Paraffin)
|
IP |
WB
|
| Dilution:
|
1:50 |
1:50 |
1:1000
|
|
Background:
The
Vascular
Endothelial Growth Factor Receptor
(VEGFR) family has three members: VEGFR-1 (also known as flt-1),
VEGFR-2 (KDR/flk-1), and VEGFR-3 (FLT4). In VEGFR-3, the
fifth Ig homology domain of the extracellular portion is
proteolytically cleaved and the resulting polypeptides remain
linked by two disulfide bonds.1 The ligands
binding to VEGFRs belong to the VEGF family of growth
factors, which has five cellular members: VEGF, placenta
growth factor (PlGF), VEGF-B, VEGF-C, VEGF-D, and the recently cloned
viral VEGF homologue VEGF-E.2 VEGFR-3 is required
for cardiovascular development during embryogenesis. In adults,
this receptor is expressed in lymphatic endothelial cells. VEGF-C
and VEGF-D are VEGFR3 ligands. The binding of VEGF ligands to VEGFRs
activates VEGFR3 signaling, which regulates cardiovascular development,
angiogenesis, and lymphangiogenesis.3
References:
1.
Otrock, Z.K. et al. :
Blood Cells Mol Dis. 38:258, 2007.
2.
Taipale, J. et al.:
Curr Top Microbiol Immunol. 237:85, 1999.
3.
Su, J.L. et al.: Br
J Cancer. 96:541, 2007.
|
|
|
