| Cat.# |
CA10245 |
| Size |
100
µg / 200 ml |
| Isotype:
|
mouse
monoclonal IgG1
|
| Epitope: |
recombinant
human Stat3 protein |
| Species: |
human,
mouse, rat |
| Storage: |
Store at 4°
for frequent use; at -20°
for at least one year |
| MW:
|
79
& 86 kDa
|
|
Application:
|
WB
|
| Dilution:
|
1:1000
|
|
Background:
Signal
transducers and activators of transcription (STATs) comprise a unique
family of transcription factors, which transmit the interactions of
cytokines, hormones and growth factors with their cell surface receptors
into transcriptional programs. The mechanism of STAT activation has been
well-established and comprises tyrosine phosphorylation, dimerization,
nuclear translocation, binding to specific DNA response elements,
recruitment of co-activators or co-repressors and transcriptional
induction or repression of target genes1. STAT3, a member of
STAT family, has been known as a mediator for gene expression induced by
many important cytokines and growth factors2. It plays
diversified roles from cell growth, differentiation, apoptosis to
oncogenesisi and stem cell renewal regulations.
Stat3 is constitutively activated in many human cancers where it
functions as a critical mediator of oncogenic signaling3.
Thus, Stat3 is also a target for cancer therapy.
References:
1.
Desrivieres,
S. et al., J Mammary Gland Biol Neoplasia. 11:75 (2006).
2.
Fu,
XY, Cell Res. 16:214 (2006).
3.
Jing, N. & Tweardy, DJ., Anticancer Drugs. 16:601 (2005).
|
|
Specific
detection of Stat3 proteins from various cell lysates in Western blot
analysis using Stat3 Monoclonal Antibody (4G28)
|
